| Short-term treatment with prostaglandin E1 analogue has long-term preventive effects on intimal thickening in balloon-injured rat carotid arteries. | |
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MedLine Citation:
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PMID: 9785382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined effects of a prostaglandin E1 analogue alprostadil on intimal thickening and arterial remodeling in balloon-injured rat carotid arteries. Right common carotid arteries were balloon-injured, and their left counterparts were sham-operated (uninjured). Rats were given alprostadil (0.3 microgram/kg/min, continuous subcutaneous (s.c.) infusion) or vehicle for 1 week after the injury and sacrificed at 4 weeks or 8 weeks. Segments of common carotid arteries corresponding to balloon-injured and uninjured sites were excised and subjected to elastica van Gieson staining. Cross-sectional areas were measured by computed planimetry. Alprostadil prevented intimal thickening at both 4 and 8 weeks. In addition, alprostadil prevented the increase in intimal area/area surrounded by external elastic lamina at both 4 and 8 weeks. Alprostadil had no effects on body weight, heart rate, or systolic blood pressure. Our study demonstrated that alprostadil administered only for the initial 1 week had long-term (up to 8 weeks) preventive effects on intimal thickening. Alprostadil may be useful to prevent restenosis after balloon angioplasty. |
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Authors:
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A Shimauchi; Y Toki; Y Numaguchi; H Mukawa; H Matsui; K Okumura; T Ito; T Hayakawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins & other lipid mediators Volume: 56 ISSN: 1098-8823 ISO Abbreviation: Prostaglandins Other Lipid Mediat. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-12-03 Completed Date: 1998-12-03 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9808648 Medline TA: Prostaglandins Other Lipid Mediat Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 119-30 Citation Subset: IM |
Affiliation:
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Nagoya University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alprostadil
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therapeutic use* Angioplasty, Balloon / adverse effects* Animals Carotid Arteries / pathology* Carotid Artery Injuries* Cell Division Endothelium, Vascular / injuries, pathology Male Muscle, Smooth, Vascular / pathology Platelet Aggregation Inhibitors Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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