| Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate. | |
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MedLine Citation:
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PMID: 9458754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of increasing a known lactate transporter protein, monocarboxylate transporter 1 (MCT1), on lactate extrusion from human skeletal muscle during exercise. Before and after short-term bicycle ergometry training [2 h/day, 7 days at 65% maximal oxygen consumption (VO2max)], subjects (n = 7) completed a continuous bicycle ergometer ride at 30% VO2max (15 min), 60% VO2max (15 min), and 75% VO2max (15 min). Muscle biopsy samples (vastus lateralis) and arterial and femoral venous blood samples were obtained before exercise and at the end of each workload. After 7 days of training the MCT1 content in muscle was increased (+18%; P < 0.05). The concentrations of both muscle lactate and femoral venous lactate were reduced during exercise (P < 0.05) that was performed after training. High correlations were observed between muscle lactate and venous lactate before training (r = 0.92, P < 0.05) and after training (r = 0.85, P < 0.05), but the slopes of the regression lines between these variables differed markedly. Before training, the slope was 0.12 +/- 0.01 mM lactate.mmol lactate-1.kg muscle dry wt-1, and this was increased by 33% after training to 0.18 +/- 0.02 mM lactate.mmol lactate-1.kg muscle dry wt-1. This indicated that after training the femoral venous lactate concentrations were increased for a given amount of muscle lactate. These results suggest that lactate extrusion from exercising muscles is increased after training, and this may be associated with the increase in skeletal muscle MCT1. |
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Authors:
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A Bonen; K J McCullagh; C T Putman; E Hultman; N L Jones; G J Heigenhauser |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 274 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-02-19 Completed Date: 1998-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E102-7 Citation Subset: IM; S |
Affiliation:
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Department of Kinesiology, University of Waterloo, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carrier Proteins / biosynthesis* Exercise / physiology* Exercise Test Femoral Artery Femoral Vein Glycogen / metabolism Humans Lactates / blood, metabolism* Male Membrane Proteins / biosynthesis Monocarboxylic Acid Transporters Muscle, Skeletal / blood supply, physiology* Oxygen Consumption Physical Endurance / physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Lactates; 0/Membrane Proteins; 0/Monocarboxylic Acid Transporters; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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