Document Detail

Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate.
MedLine Citation:
PMID:  9458754     Owner:  NLM     Status:  MEDLINE    
We examined the effects of increasing a known lactate transporter protein, monocarboxylate transporter 1 (MCT1), on lactate extrusion from human skeletal muscle during exercise. Before and after short-term bicycle ergometry training [2 h/day, 7 days at 65% maximal oxygen consumption (VO2max)], subjects (n = 7) completed a continuous bicycle ergometer ride at 30% VO2max (15 min), 60% VO2max (15 min), and 75% VO2max (15 min). Muscle biopsy samples (vastus lateralis) and arterial and femoral venous blood samples were obtained before exercise and at the end of each workload. After 7 days of training the MCT1 content in muscle was increased (+18%; P < 0.05). The concentrations of both muscle lactate and femoral venous lactate were reduced during exercise (P < 0.05) that was performed after training. High correlations were observed between muscle lactate and venous lactate before training (r = 0.92, P < 0.05) and after training (r = 0.85, P < 0.05), but the slopes of the regression lines between these variables differed markedly. Before training, the slope was 0.12 +/- 0.01 mM lactate.mmol muscle dry wt-1, and this was increased by 33% after training to 0.18 +/- 0.02 mM lactate.mmol muscle dry wt-1. This indicated that after training the femoral venous lactate concentrations were increased for a given amount of muscle lactate. These results suggest that lactate extrusion from exercising muscles is increased after training, and this may be associated with the increase in skeletal muscle MCT1.
A Bonen; K J McCullagh; C T Putman; E Hultman; N L Jones; G J Heigenhauser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-19     Completed Date:  1998-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E102-7     Citation Subset:  IM; S    
Department of Kinesiology, University of Waterloo, Ontario, Canada.
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MeSH Terms
Carrier Proteins / biosynthesis*
Exercise / physiology*
Exercise Test
Femoral Artery
Femoral Vein
Glycogen / metabolism
Lactates / blood,  metabolism*
Membrane Proteins / biosynthesis
Monocarboxylic Acid Transporters
Muscle, Skeletal / blood supply,  physiology*
Oxygen Consumption
Physical Endurance / physiology*
Time Factors
Reg. No./Substance:
0/Carrier Proteins; 0/Lactates; 0/Membrane Proteins; 0/Monocarboxylic Acid Transporters; 9005-79-2/Glycogen

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