Document Detail


Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate.
MedLine Citation:
PMID:  9458754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of increasing a known lactate transporter protein, monocarboxylate transporter 1 (MCT1), on lactate extrusion from human skeletal muscle during exercise. Before and after short-term bicycle ergometry training [2 h/day, 7 days at 65% maximal oxygen consumption (VO2max)], subjects (n = 7) completed a continuous bicycle ergometer ride at 30% VO2max (15 min), 60% VO2max (15 min), and 75% VO2max (15 min). Muscle biopsy samples (vastus lateralis) and arterial and femoral venous blood samples were obtained before exercise and at the end of each workload. After 7 days of training the MCT1 content in muscle was increased (+18%; P < 0.05). The concentrations of both muscle lactate and femoral venous lactate were reduced during exercise (P < 0.05) that was performed after training. High correlations were observed between muscle lactate and venous lactate before training (r = 0.92, P < 0.05) and after training (r = 0.85, P < 0.05), but the slopes of the regression lines between these variables differed markedly. Before training, the slope was 0.12 +/- 0.01 mM lactate.mmol lactate-1.kg muscle dry wt-1, and this was increased by 33% after training to 0.18 +/- 0.02 mM lactate.mmol lactate-1.kg muscle dry wt-1. This indicated that after training the femoral venous lactate concentrations were increased for a given amount of muscle lactate. These results suggest that lactate extrusion from exercising muscles is increased after training, and this may be associated with the increase in skeletal muscle MCT1.
Authors:
A Bonen; K J McCullagh; C T Putman; E Hultman; N L Jones; G J Heigenhauser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-19     Completed Date:  1998-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E102-7     Citation Subset:  IM; S    
Affiliation:
Department of Kinesiology, University of Waterloo, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carrier Proteins / biosynthesis*
Exercise / physiology*
Exercise Test
Femoral Artery
Femoral Vein
Glycogen / metabolism
Humans
Lactates / blood,  metabolism*
Male
Membrane Proteins / biosynthesis
Monocarboxylic Acid Transporters
Muscle, Skeletal / blood supply,  physiology*
Oxygen Consumption
Physical Endurance / physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Lactates; 0/Membrane Proteins; 0/Monocarboxylic Acid Transporters; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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