Document Detail


Short-term tests for transplacentally active carcinogens. I. Micronucleus formation in fetal and maternal mouse erythroblasts.
MedLine Citation:
PMID:  7207479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A cell-kinetic model for the application of the micronucleus test to polychromatic erythrocytes in mouse fetal liver, fetal blood, and maternal bone marrow after exposure to clastogenic agents is described. The time of expression and dose-response relationships obtained with gamma-radiation, methyl methanesulphonate, procarbazine, mitomycin C and benzo[a]pyrene are analysed in terms of this model. The numbers of target cells damaged per unit dose has been calculated and the dose equivalents obtained. Maternal and fetal cells show similar sensitivity to gamma-radiation, but fetal cells are markedly more sensitive to MMS and procarbazine. This probably due to differences in tissue distribution and metabolism. Maternal and fetal erythroid tissues can show linear and exponential dose-response relationships, which may not coincide (e.g. with MMS). It is concluded that risks from fetal exposure to genotoxic agents cannot be reliably predicted from in vivo tests restricted to adult animals. However, the micronucleus technique applied to fetal erythroid cells provides a rapid and reliable short-term test, appropriate to minimising risks of genome damage during prenatal development.
Authors:
R J Cole; N Taylor; J Cole; C F Arlett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  80     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  141-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / pharmacology*
Cell Nucleus
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Erythroblasts / ultrastructure
Female
Gamma Rays
Kinetics
Maternal-Fetal Exchange*
Methyl Methanesulfonate / pharmacology
Mice
Mitomycins / pharmacology
Models, Genetic*
Mutagenicity Tests
Mutagens*
Pregnancy
Procarbazine / pharmacology
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Mitomycins; 0/Mutagens; 66-27-3/Methyl Methanesulfonate; 671-16-9/Procarbazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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