Document Detail


Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent.
MedLine Citation:
PMID:  11090255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vegans do not consume meat and fish and have therefore low intakes of long chain polyunsaturated fatty acids (LCP). They may consequently have little negative feedback inhibition from dietary LCP on conversion of alpha -linolenic acid (ALA) to the LCP omega 3 eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. We investigated whether supplementation of nine apparently healthy vegans with 2.01 g ALA (4 ml linseed oil), 1.17 g gamma-linolenic acid (GLA) (6 ml borage oil) or their combination increases the LCP omega 3 contents of erythrocytes (RBC) and platelets (PLT), and of plasma phospholipids (PL), cholesterol esters (CE) and triglycerides (TG). The supplements changed the dietary LA/ALA ratio (in g/g) from about 13.7 (baseline) to 6.8 (linseed oil), 14.3 (borage oil) and 6.4 (linseed + borage oil), respectively. ALA or GLA given as single supplements did not increase LCP omega 3 status, but their combination augmented LCP omega 3 (in CE) and EPA (in fasting TG) to a statistically significant, but nevertheless negligible, extent. We conclude that negative feedback inhibition by dietary LCP, if any, does not play an important role in the inability to augment notably DHA status by dietary ALA. The reach of a DHA plateau already at low dietary ALA intakes suggests that dietary DHA causes a non-functional DHA surplus, or is, alternatively, important for maintaining DHA status at a functionally relevant level.
Authors:
M R Fokkema; D A Brouwer; M B Hasperhoven; I A Martini; F A Muskiet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  63     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Harcourt Publishers Ltd.
Affiliation:
Department of Pathology and Laboratory Medicine, Groningen University Hospital, Groningen, The Netherlands. m.r.fokkema@path.azg.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Platelets / drug effects,  metabolism
Cholesterol Esters / blood
Diet, Vegetarian*
Dietary Supplements*
Docosahexaenoic Acids / blood
Eicosapentaenoic Acid / blood
Erythrocytes / drug effects,  metabolism
Fatty Acids, Unsaturated / blood*
Female
Humans
Male
Middle Aged
Netherlands
Phospholipids / blood
Triglycerides / blood
alpha-Linolenic Acid / metabolism*
gamma-Linolenic Acid / metabolism*
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 506-26-3/gamma-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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