| Short-term safety assessment of clobetasol propionate 0.05% shampoo: hypothalamic-pituitary-adrenal axis suppression, atrophogenicity, and ocular safety in subjects with scalp psoriasis. | |
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MedLine Citation:
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PMID: 16673799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clobetasol propionate is known to be a very effective treatment for psoriasis; however, its use is limited by potent corticosteroid class related side effects such as hypothalamic-pituitary-adrenal (HPA) axis suppression and atrophogenicity. The aim of this single-center, parallel group, randomized study was to assess the HPA axis suppression potential, atrophogenicity, and ocular tolerability of clobetasol propionate shampoo in 26 patients with scalp psoriasis. Suitable subjects were treated once daily for 4 weeks with clobetasol propionate shampoo, to be rinsed off after 15 minutes or with a leave-on clobetasol propionate gel. The study demonstrated that clobetasol propionate shampoo did not lead to HPA axis suppression or to skin atrophy. Conversely, the gel led to HPA axis suppression and a decrease in skin thickness. Neither formulation had an impact on ocular safety. Despite the short contact application time, the clobetasol propionate shampoo provides similar efficacy results to the gel. |
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Authors:
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Philippe Andres; Michel Poncet; Sidou Farzaneh; Pascale Soto |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of drugs in dermatology : JDD Volume: 5 ISSN: 1545-9616 ISO Abbreviation: J Drugs Dermatol Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-05-05 Completed Date: 2006-09-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101160020 Medline TA: J Drugs Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 328-32 Citation Subset: IM |
Affiliation:
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Galderma R&D, Sophia Antipolis, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adult Atrophy / chemically induced Clobetasol / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Drug Administration Schedule Female Hair Preparations / chemistry* Humans Hypothalamo-Hypophyseal System / drug effects, physiology Male Middle Aged Ocular Physiological Phenomena / drug effects Pituitary-Adrenal System / drug effects, physiology Psoriasis / drug therapy* Scalp Dermatoses / drug therapy* Skin / drug effects, pathology Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Hair Preparations; 25122-41-2/Clobetasol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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