Document Detail


Short-term safety assessment of clobetasol propionate 0.05% shampoo: hypothalamic-pituitary-adrenal axis suppression, atrophogenicity, and ocular safety in subjects with scalp psoriasis.
MedLine Citation:
PMID:  16673799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clobetasol propionate is known to be a very effective treatment for psoriasis; however, its use is limited by potent corticosteroid class related side effects such as hypothalamic-pituitary-adrenal (HPA) axis suppression and atrophogenicity. The aim of this single-center, parallel group, randomized study was to assess the HPA axis suppression potential, atrophogenicity, and ocular tolerability of clobetasol propionate shampoo in 26 patients with scalp psoriasis. Suitable subjects were treated once daily for 4 weeks with clobetasol propionate shampoo, to be rinsed off after 15 minutes or with a leave-on clobetasol propionate gel. The study demonstrated that clobetasol propionate shampoo did not lead to HPA axis suppression or to skin atrophy. Conversely, the gel led to HPA axis suppression and a decrease in skin thickness. Neither formulation had an impact on ocular safety. Despite the short contact application time, the clobetasol propionate shampoo provides similar efficacy results to the gel.
Authors:
Philippe Andres; Michel Poncet; Sidou Farzaneh; Pascale Soto
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  5     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-05     Completed Date:  2006-09-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-32     Citation Subset:  IM    
Affiliation:
Galderma R&D, Sophia Antipolis, France.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Atrophy / chemically induced
Clobetasol / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Drug Administration Schedule
Female
Hair Preparations / chemistry*
Humans
Hypothalamo-Hypophyseal System / drug effects,  physiology
Male
Middle Aged
Ocular Physiological Phenomena / drug effects
Pituitary-Adrenal System / drug effects,  physiology
Psoriasis / drug therapy*
Scalp Dermatoses / drug therapy*
Skin / drug effects,  pathology
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Hair Preparations; 25122-41-2/Clobetasol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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