Document Detail


Short-term residential cardiac rehabilitation reduces B-type natriuretic peptide.
MedLine Citation:
PMID:  19494782     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The inactive N-terminal pro-BNP (NT-proBNP) serves as a marker of heart failure. We evaluated the effects of moderate exercise on NT-proBNP and other cardiovascular disease risk factors in 359 consecutive patients admitted for residential cardiovascular rehabilitation. METHODS AND RESULTS: Patients underwent cycle ergometry, blood sampling, and fasting glucose tests at the beginning and end of 25+/-4 days of the exercise program. Maximal oxygen uptake (VO2max) was estimated from the maximal watts achieved. The program consisted of cycling for 17+/-4 min, 6 times/week, and daily walking for 45 min at intensity of 60-70% of the individual maximal heart rate (HR). Patients underwent echocardiographic examination and were categorized according to left ventricular ejection fraction. NT-proBNP decreased to 29% (P = 0.001) for entire group after training. Maximal performance and VO2max improved significantly (P = 0.001). NT-proBNP was inversely related to pulse pressure at maximal exercise (-0.39), HR range (-0.35), and HR recovery in 1 min (-0.28). CONCLUSION: Four weeks of exercise reduced NT-proBNP, independent of left ventricular ejection fraction, and improved physical fitness and blood lipid profiles. NT-proBNP as a prognostic biomarker of heart failure patients was reduced and was inversely related to maximal performance and VO2max.
Authors:
Robert Berent; Serge P von Duvillard; Stephen F Crouse; Johann Auer; John S Green; Helmut Sinzinger; Peter Schmid
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology     Volume:  16     ISSN:  1741-8275     ISO Abbreviation:  Eur J Cardiovasc Prev Rehabil     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-01-06     Completed Date:  2010-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101192000     Medline TA:  Eur J Cardiovasc Prev Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  603-8     Citation Subset:  IM    
Affiliation:
Center for Cardiovascular Rehabilitation, Rehabilitationszentrum Austria, Stifterstrasse 11, Bad Schallerbach 4701, Austria. robert.berent@aon.at
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Blood Pressure
Cardiovascular Agents / therapeutic use
Down-Regulation
Echocardiography
Exercise Test
Exercise Therapy*
Female
Heart Failure / blood,  drug therapy,  physiopathology,  rehabilitation*
Heart Rate
Humans
Lipids / blood
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Oxygen Consumption
Peptide Fragments / blood*
Residential Treatment*
Stroke Volume
Time Factors
Treatment Outcome
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cardiovascular Agents; 0/Lipids; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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