| Short-term residential cardiac rehabilitation reduces B-type natriuretic peptide. | |
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MedLine Citation:
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PMID: 19494782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The inactive N-terminal pro-BNP (NT-proBNP) serves as a marker of heart failure. We evaluated the effects of moderate exercise on NT-proBNP and other cardiovascular disease risk factors in 359 consecutive patients admitted for residential cardiovascular rehabilitation. METHODS AND RESULTS: Patients underwent cycle ergometry, blood sampling, and fasting glucose tests at the beginning and end of 25+/-4 days of the exercise program. Maximal oxygen uptake (VO2max) was estimated from the maximal watts achieved. The program consisted of cycling for 17+/-4 min, 6 times/week, and daily walking for 45 min at intensity of 60-70% of the individual maximal heart rate (HR). Patients underwent echocardiographic examination and were categorized according to left ventricular ejection fraction. NT-proBNP decreased to 29% (P = 0.001) for entire group after training. Maximal performance and VO2max improved significantly (P = 0.001). NT-proBNP was inversely related to pulse pressure at maximal exercise (-0.39), HR range (-0.35), and HR recovery in 1 min (-0.28). CONCLUSION: Four weeks of exercise reduced NT-proBNP, independent of left ventricular ejection fraction, and improved physical fitness and blood lipid profiles. NT-proBNP as a prognostic biomarker of heart failure patients was reduced and was inversely related to maximal performance and VO2max. |
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Authors:
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Robert Berent; Serge P von Duvillard; Stephen F Crouse; Johann Auer; John S Green; Helmut Sinzinger; Peter Schmid |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 16 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-01-06 Completed Date: 2010-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 603-8 Citation Subset: IM |
Affiliation:
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Center for Cardiovascular Rehabilitation, Rehabilitationszentrum Austria, Stifterstrasse 11, Bad Schallerbach 4701, Austria. robert.berent@aon.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Blood Pressure Cardiovascular Agents / therapeutic use Down-Regulation Echocardiography Exercise Test Exercise Therapy* Female Heart Failure / blood, drug therapy, physiopathology, rehabilitation* Heart Rate Humans Lipids / blood Male Middle Aged Natriuretic Peptide, Brain / blood* Oxygen Consumption Peptide Fragments / blood* Residential Treatment* Stroke Volume Time Factors Treatment Outcome Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cardiovascular Agents; 0/Lipids; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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