| Short-term regulation of hepatic triacylglycerol metabolism by insulin and glucagon. | |
| | |
MedLine Citation:
|
PMID: 7051525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This paper presents a review of our current knowledge of short-term regulation of triacylglycerol metabolism by insulin and glucagon in isolated rat hepatocytes. Insulin is devoted to rapidly improve the lipogenic climate of the hepatocyte. The hormone stimulates glycolysis, the conversion of pyruvate into acetyl-CoA, the synthesis of fatty acids and their esterification. The opposite pathways, hydrolysis of triacylglycerols and fatty acid oxidation, are depressed by insulin. Glucagon does all but deteriorate the lipogenic climate within the liver cell as the hormone inhibits triacylglycerol synthesis and stimulates the breakdown of triacylglycerols. |
| | |
Authors:
|
A C Beynen; M J Geelen |
Related Documents
:
|
2495825 - In vitro studies of the thyroglobulin degradation pathway: endocytosis and delivery of ... 2001235 - Regulation of fatty acid metabolism and gluconeogenesis by growth hormone and insulin i... 13886645 - The amino acid composition of human pituitary growth hormone. 2574405 - Stimulation of pituitary hormone secretion by neurotransmitter amino acids in humans. 6775435 - Influence of edta and its metal complexes on lactic acid fermentation. 23512965 - Metabolomic signatures in lipid-loaded hepargs reveal pathways involved in steatotic pr... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Veterinary research communications Volume: 5 ISSN: 0165-7380 ISO Abbreviation: Vet. Res. Commun. Publication Date: 1982 May |
Date Detail:
|
Created Date: 1982-10-29 Completed Date: 1982-10-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8100520 Medline TA: Vet Res Commun Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 223-36 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cells, Cultured Esterification Fatty Acids / biosynthesis, metabolism Glucagon / pharmacology, physiology* Glycolysis Hydrolysis Insulin / pharmacology, physiology* Liver / metabolism*, secretion Mitochondria, Liver / metabolism Pyruvate Dehydrogenase Complex / metabolism Rats Triglycerides / biosynthesis, metabolism*, secretion |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Pyruvate Dehydrogenase Complex; 0/Triglycerides; 11061-68-0/Insulin; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimization and kinetics of in vitro stimulation of carp (Cyprinus carpio L.) leukocytes.
Next Document: Ruminant thiamine requirement in perspective.