Document Detail


Short-term regulation of hepatic triacylglycerol metabolism by insulin and glucagon.
MedLine Citation:
PMID:  7051525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper presents a review of our current knowledge of short-term regulation of triacylglycerol metabolism by insulin and glucagon in isolated rat hepatocytes. Insulin is devoted to rapidly improve the lipogenic climate of the hepatocyte. The hormone stimulates glycolysis, the conversion of pyruvate into acetyl-CoA, the synthesis of fatty acids and their esterification. The opposite pathways, hydrolysis of triacylglycerols and fatty acid oxidation, are depressed by insulin. Glucagon does all but deteriorate the lipogenic climate within the liver cell as the hormone inhibits triacylglycerol synthesis and stimulates the breakdown of triacylglycerols.
Authors:
A C Beynen; M J Geelen
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Veterinary research communications     Volume:  5     ISSN:  0165-7380     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  223-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Esterification
Fatty Acids / biosynthesis,  metabolism
Glucagon / pharmacology,  physiology*
Glycolysis
Hydrolysis
Insulin / pharmacology,  physiology*
Liver / metabolism*,  secretion
Mitochondria, Liver / metabolism
Pyruvate Dehydrogenase Complex / metabolism
Rats
Triglycerides / biosynthesis,  metabolism*,  secretion
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Pyruvate Dehydrogenase Complex; 0/Triglycerides; 11061-68-0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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