Document Detail

Short term prognostic role of NT-proBNP in patients after myocardial infarction.
MedLine Citation:
PMID:  19202516     Owner:  NLM     Status:  MEDLINE    
AIM: The clinical and prognostic role of cardiac natriuretic peptides (CNP) in patients with heart failure is well known; recently, several studies have evaluated the possibility of using CNP to evaluate their potential prognostic role in patients with acute coronary syndromes (ACS). The aim of this study was to evaluate the short term prognostic value of NT-proBNP in 70 patients admitted for ACS. METHODS: The authors studied 70 patients with ACS, evaluating, at admission, clinical-anamnestic, instrumental and laboratory characteristics including NT-proBNP plasma levels. Patients were monitored in a 6-month-follow-up to record adverse fatal events and their possible correlation with baseline characteristics. RESULTS: The incidence of adverse events during the follow-up period was 28% (10 patients). In patients with adverse events, the authors observed lower left ventricle ejection fraction (P=0.01), higher prevalence of ST elevation myocardial infarction (P=0.03) and higher NT-proBNP levels (P=0.03), compared to those without adverse events. Moreover, the logistic regression analysis underlined how ST elevation myocardial infarction (P=0.05) and higher NT-proBNP levels (P=0.05) were the only predictive variables for adverse events during the follow up period. CONCLUSIONS: This study demonstrates the short term prognostic role of NT-pro BNP in patients admitted for ACS.
G Coppola; E Corrado; S Augugliaro; M C Mulè; A Rotolo; G Ciaramitaro; M Farinella; G Evola; G Novo; S Evola; G Andolina; M Caruso; V Cospite; F Vitale; E Hoffmann; P Assennato; S Novo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  57     ISSN:  0026-4725     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
Secondary Prevention, Unit of Cardiology, Department of Internal Medicine, Paolo Giaccone Policlinic, University of Palermo, Palermo, Italy.
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MeSH Terms
Biological Markers / blood
Follow-Up Studies
Logistic Models
Middle Aged
Myocardial Infarction / blood*
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Predictive Value of Tests
Retrospective Studies
Risk Factors
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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