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Short-term prognosis of occupational asthma in a Finnish population.
MedLine Citation:
PMID:  21679349     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background:  Causative agents of occupational asthma (OA) are well described in literature but far less is known about factors affecting the outcome of OA. Short duration of exposure, early diagnosis when symptoms appear and further avoidance of exposure have been suggested as good prognostic factors. This study was designed to investigate a short-term outcome of OA. Methods:  The medical records of 47 Caucasian patients from a Finnish population diagnosed with OA in year 2003 were reviewed retrospectively. Employment status at 6-month follow-up of all patients was determined. We assessed the following potential predictors of unemployment at follow-up: the causative agents of OA, asthma medication, spirometry results, smoking status, gender, age, occupation, atopy status, bronchial hyperresponsiveness and time to diagnosis. We calculated odd ratios (ORs) to predict employment status at follow-up. Results:  At the follow-up examination, 23 persons (49%) were not working. At the time of follow-up there were no significant differences in pulmonary function between those employed and those who discontinued to work. Atopy at baseline predicted diminished lung function at the 6-month follow-up. In addition, atopy was the only prognostic factor and was inversely related to the work discontinuation at the follow-up [OR 0.18, 95% confidence interval (CI) 0.04-0.79]. Work continuation as an OA outcome at 6 months could not be predicted by gender, age, occupational status, exposure antigen, smoking habits or duration of symptoms before diagnosis. Conclusions:  The socio-economic short-term prognosis of OA was relatively poor since half of the patients were not at work at the 6 months follow-up. Please cite this paper as: Kauppi P, Hannu T, Helaskoski E, Toivio P and Sauni R. Short-term prognosis of occupational asthma in a Finnish population. Clin Respir J 2011; 5: 143-149.
Authors:
Paula Kauppi; Timo Hannu; Eva Helaskoski; Pauliina Toivio; Riitta Sauni
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Publication Detail:
Type:  Journal Article     Date:  2010-05-21
Journal Detail:
Title:  The clinical respiratory journal     Volume:  5     ISSN:  1752-699X     ISO Abbreviation:  Clin Respir J     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101315570     Medline TA:  Clin Respir J     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Skin and Allergy Hospital, Helsinki, Finland Finnish Institute of Occupational Health, Helsinki, Finland Finnish Institute of Occupational Health, Tampere, Finland.
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