Document Detail

Short-term outcomes following intrauterine transfusion in Scotland.
MedLine Citation:
PMID:  19395394     Owner:  NLM     Status:  MEDLINE    
AIM: To describe neonatal outcomes following intrauterine transfusion (IUT) for severe Rhesus isoimmunisation from 1993 to 2004.
RESULTS: 116 neonates who had undergone 457 IUTs (median 4, range 1-9) were identified. Three neonates died, all before 1995 (two because of hypoxic ischaemic multiorgan failure and one because of overwhelming Escherichia coli sepsis). 13 neonates (11%) were delivered by emergency Caesarean section following either IUT complication or spontaneous onset of preterm labour. They were more likely to require intubation (p<0.0001), on-going respiratory support (p=0.0007) and an exchange transfusion (p=0.007). 23 (20%) required an exchange transfusion and 63 (54%) at least one top-up transfusion.
CONCLUSIONS: Management of severe Rhesus disease is associated with encouraging neonatal outcomes and most infants can be managed with phototherapy and a few top-up transfusions. IUT complications are rare but significantly increase neonatal mortality and morbidity. Antenatal counselling should address the likely postnatal course for these infants.
Laura McGlone; J H Simpson; C Scott-Lang; A D Cameron; J Brennand
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Publication Detail:
Type:  Journal Article     Date:  2009-04-23
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  96     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-23     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F69-70     Citation Subset:  AIM; IM    
Queen Mother's Hospital, Dalnair Street, Glasgow, Scotland, UK.
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MeSH Terms
Blood Transfusion, Intrauterine* / adverse effects
Cesarean Section
Exchange Transfusion, Whole Blood
Gestational Age
Infant, Newborn
Perinatal Care / methods
Pregnancy Outcome
Retrospective Studies
Rh Isoimmunization / therapy*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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