|Short-term and one-year outcome of infective endocarditis in adult patients treated in a Finnish teaching hospital during 1980-2004.|
|Jump to Full Text|
|PMID: 17640339 Owner: NLM Status: MEDLINE|
|BACKGROUND: Previous studies on factors predicting the prognosis of infective endocarditis have given somewhat conflicting results. Our aim was to define the factors predicting the outcome of patients treated in a Finnish teaching hospital. METHODS: A total of 326 episodes of infective endocarditis in 303 patients treated during 1980-2004 were evaluated for short-term and 1-year outcome and complications. RESULTS: Infection of 2 native valves and the occurrence of neurological complications, peripheral emboli, or heart failure significantly predicted both in-hospital and 1-year mortality, while age > or =65 years or the presence of a major criterion or vegetation on echocardiography predicted death within 1 year. A significant trend was observed between the level of serum C-reactive protein (CRP) on admission and both the short-term and 1-year outcome. In the patients who had CRP values > or =100 mg/l on admission, the hazard ratio for in-hospital death was 2.9-fold and the hazard ratio for 1-year death was 3.9-fold as compared to those with lower CRP values. Male sex and age < 64 years significantly predicted a need for both in-hospital and 1-year surgery, as did the development of heart failure or the presence of a major criterion or vegetation on echocardiography. Peripheral emboli were associated with a need for in-hospital surgery, while Streptococcus pneumoniae as the causative agent or infection of 2 native valves predicted a need for surgery within 1 year from admission. CONCLUSION: Some of the factors (e.g. heart failure, neurological complications, peripheral emboli) predicting a poor prognosis and/or need for surgery were the same observed in previous studies. A new finding was that high CRP values (> or =100 mg/l) on admission significantly predicted both short-term and 1-year mortality.|
|Maija Heiro; Hans Helenius; Saija Hurme; Timo Savunen; Erik Engblom; Jukka Nikoskelainen; Pirkko Kotilainen|
Related Documents :
|9852889 - Valve replacement in chronic aortic regurgitation. true predictors of survival after ex...
7073379 - Aspirin or coumadin as the drug of choice for valve replacement with porcine bioprosthe...
10874609 - Late results with bioprosthetic valves in the elderly.
20019449 - The value of real-time three-dimensional transesophageal echocardiography in the assess...
6426359 - Treatment of streptomycin-susceptible and streptomycin-resistant enterococcal endocardi...
4058039 - Comparison of bioprosthetic and mechanical valve replacement for active endocarditis.
2277369 - Endometrial ablation with the roller ball electrode.
20839689 - Total hip arthroplasty in patients with down syndrome.
2213309 - A protocol for management of temporomandibular joint ankylosis.
|Type: Journal Article Date: 2007-07-17|
|Title: BMC infectious diseases Volume: 7 ISSN: 1471-2334 ISO Abbreviation: BMC Infect. Dis. Publication Date: 2007|
|Created Date: 2007-08-16 Completed Date: 2007-09-10 Revised Date: 2009-11-18|
Medline Journal Info:
|Nlm Unique ID: 100968551 Medline TA: BMC Infect Dis Country: England|
|Languages: eng Pagination: 78 Citation Subset: IM|
|Department of Medicine, Turku University Hospital, Turku, Finland. firstname.lastname@example.org <email@example.com>|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Embolism / complications, microbiology
Endocarditis, Bacterial / complications, microbiology, mortality*
Heart Valve Diseases / complications, microbiology, mortality*, surgery
Nervous System Diseases / complications, microbiology
Journal ID (nlm-ta): BMC Infect Dis
Publisher: BioMed Central, London
Copyright ? 2007 Heiro et al; licensee BioMed Central Ltd.
open-access: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 19 Month: 12 Year: 2006
Accepted Day: 17 Month: 7 Year: 2007
collection publication date: Year: 2007
Electronic publication date: Day: 17 Month: 7 Year: 2007
Volume: 7First Page: 78 Last Page: 78
Publisher Id: 1471-2334-7-78
PubMed Id: 17640339
|Short-term and one-year outcome of infective endocarditis in adult patients treated in a Finnish teaching hospital during 1980?2004|
|Maija Heiro1||Email: firstname.lastname@example.org|
|Hans Helenius2||Email: email@example.com|
|Saija Hurme2||Email: firstname.lastname@example.org|
|Timo Savunen3||Email: email@example.com|
|Erik Engblom1||Email: firstname.lastname@example.org|
|Jukka Nikoskelainen1||Email: email@example.com|
|Pirkko Kotilainen1||Email: firstname.lastname@example.org|
1Department of Medicine, Turku University Hospital, Turku, Finland
2Department of Biostatistics, University of Turku, Turku, Finland
3Department of Surgery, Turku University Hospital, Turku, Finland
Infective endocarditis is a diagnostic and therapeutic challenge to clinicians. Despite major advances in cardiac imaging technology, antimicrobial treatment and surgical techniques, the morbidity and mortality associated with infective endocarditis remains high. Several previous studies from the 1990's and 2000's show that mortality of endocarditis is still from 10% to 24% [1-6]. Some authors report a decreasing trend in mortality, and this has been attributed either to lower operative mortality , or technically more successful early valve surgery . Previous studies have attempted to identify various clinical and microbial factors predicting either short-term or long-term mortality of infective endocarditis, with somewhat conflicting results [5,8-12].
Our previous reports on patients treated for infective endocarditis in our hospital from 1980 onwards have focused on diagnostic classification, neurological manifestations, and the utility of the serum C-reactive protein (CRP) in assessing the outcome of the disease [13-15]. We have also published the changes we have seen in the presentation of endocarditis during the past 25 years . In the present study, we analyse the short-term and 1-year clinical outcome of these patients in more detail with the aim to delineate the factors predicting an adverse outcome in patients treated for endocarditis in a Finnish teaching hospital.
The short-term and 1-year outcome of infective endocarditis was analysed in 303 patients with 326 episodes of the disease treated at the Turku University Hospital, Turku, Finland, between 1980 and 2004. The hospital is a 1000-bed teaching facility with a cardiothoracic surgical department, serving as a tertiary referral centre for the southwestern part of the country, and as a primary care facility for infectious diseases for a region of about 200.000 inhabitants.
For each patient, data on age, sex, underlying diseases, causative agents of infective endocarditis, affected valves and echocardiographic findings, as well as the development of complications were collected by us for our previous study focusing on the changes of the clinical characteristics of endocarditis during the 25-year period . For the present study, the mortality and the need for surgical treatment were recorded in detail for all patients during a period of 1 year from admission. In addition to hospital records, dates of possible deaths were obtained from the National Population Registry, in which all deaths and causes of deaths of the Finnish residents are registered. CRP and erythrocyte sedimentation rate (ESR) values and white blood cell (WBC) counts on admission were also registered. The data were used to analyse the association between various patient and disease characteristics and the development of complications, mode of treatment and mortality of infective endocarditis. The factors predicting a poor short-term and 1-year clinical outcome and the requirement for surgical treatment were also delineated.
Short-term outcome was defined as the outcome during the index hospitalisation.
The study was approved by the Institutional Committee on human research.
The associations between the clinical characteristics and cumulative mortality or cumulative need for surgery was studied using survival (or event history) analysis. First, during different time periods the cumulative percentages for death (table 1) or for need of surgery (table 2) were estimated using Kaplan-Meyer technique. Differences in cumulative percentages between groups were tested using log-rank test. Differences between groups were quantified by calculating hazard ratios using Cox's regression models (tables 4 and 5). Associations between in-hospital complications and death or need for surgery were tested using chi squared test. P-values less than 0.05 were considered as statistically significant. Statistical computations were carried out using SAS? release 9.1/2005.
Of the 326 episodes, 224 were designated as definite infective endocarditis and the rest as possible infective endocarditis by the Duke criteria . There were 234 episodes in men and 92 episodes in women. The mean age (SD) was 54.4 (17.3) years (range 18 to 87 years). Transthoracic echocardiography (TTE) was performed in all episodes of IE, followed by transesophageal echocardiography (TEE) in 184 episodes. The characteristics of the patients are presented in tables 1 and 2.
Fifty-three patients died of infective endocarditis during 1 year from admission; 23 of them within 30 days from admission, and 20 between 1 and 3 months after admission. The cumulative mortality in various patient groups is presented in table 1. Mortality was significantly associated with age (?65 years) except during the index hospitalisation, but not with gender. At all time points, mortality was significantly higher in Streptococcus pneumoniae endocarditis than in endocarditis caused by other pathogens or in culture-negative cases (all p values < 0.006), and significantly higher in infections of 2 native valves than in infections affecting only one native valve or a prosthetic valve (all p values < 0.001). At 3 months, mortality of Staphylococcus aureus endocarditis was significantly higher than mortality of endocarditis caused by other pathogens excluding S. pneumoniae (p = 0.032). At 6 months, the difference still seemed to exist, but did not reach statistical significance (p = 0.061). Mortality was significantly associated with the occurrence of neurological complications, peripheral emboli (except at 3 months), and heart failure before 3 months after admission. There were no statistically significant differences in the outcome between the patients with different neurological complications (embolic brain infarction, brain haemorrhage, transient ischaemic stroke, meningitis) (p values between 0.737 to 0.934). At 6 months and 1 year, mortality was associated with the presence of a major criterion or a vegetation on echocardiography, and at 3 months, also with the presence of a vegetation. Mortality was not significantly associated with conditions like diabetes, collagenosis, malignancy, or intravenous drug use (IVDU) (all p values > 0.065).
During the study period, mortalities were not different for the patients who were treated surgically or conservatively during the index hospitalisation (table 1).
Data on serum CRP value, ESR, WBC count, and serum creatinine value on admission was available in 272, 192, 290, and 282 episodes of endocarditis, respectively. At all time points, mortality was significantly higher among the patients with CRP values ?100 mg/l on admission than among those with lower CRP values. The patients with serum creatinine values ?100 ?mol/l on admission had a significantly higher mortality at 3 months, but not later, than the patients with normal serum creatinine values. The ESR (?50 mm/h) or WBC counts (?10 ? 109/l) on admission did not associate with mortality (all p values > 0.188).
Of the 109 cardiac operations performed within 1 year after diagnosis, 43 were done within 2 weeks, 16 between 2 and 4 weeks, and 35 between 1 and 3 months. The cumulative proportion of the patients requiring surgical treatment is presented in table 2. The requirement for surgery was at all time points significantly higher in men and in patients < 64 years of age. The need for surgery was unrelated to the causative microorganism. The proportion of the episodes requiring surgical treatment was highest for cases where 2 native valves were infected, with a significant difference between the involvement of 2 valves and all other valve sites as a group (all p values < 0.01).
The requirement for surgery was significantly associated with heart failure and the presence of a major criterion or vegetation on echocardiography. The need for surgery was not different in the patients with background conditions such as diabetes, collagenosis, or malignancy (all p values > 0.080). Patients with IVDU required surgery after 6 months to 1 year significantly less often than those with no IVDU.
There was a trend for a more common requirement for surgery during the index hospitalisation in patients with CRP values ?100 mg/l on admission as compared to those with lower CRP values, but the difference did not reach statistical significance (p = 0.060). Patients with ESR ?50 mm/h on admission required surgery significantly less often than those with lower ESR values at all time points. Elevated levels of the WBC count (?10 ? 109/l) or serum creatinine (?100 ?mol/l) on admission were not significantly associated with the need for surgery.
The association between the clinical characteristics and the development of in-hospital complications of infective endocarditis are shown in table 3. Of the 86 patients who had neurological complications, the complication was manifested already on admission in 68.6% (59/86), within 1 week from admission in 76.7% (66/86), and within 2 weeks of admission in 86.1% (74/86) of the patients. There were significant differences in the frequency of neurological complications between infective endocarditis caused by different pathogens, these complications being most common in episodes caused by S. pneumoniae and least common in blood culture-negative endocarditis. Neurological complications were most common in infections of 2 native valves, and least common if only the tricuspid valve was infected, but the differences between infections of various valve sites were not significant. There was no difference in the frequency of all neurological complications or major cerebral emboli between the episodes with or without a vegetation, or with or without a major criterion, detected on echocardiography.
Of the 102 patients who had peripheral emboli, the complication was manifested already on admission in 55.9% (57/102), within 1 week from admission in 82.4% (84/102), and within 2 weeks from admission in 88.2% (90/102). Significant differences in the development of peripheral emboli were also observed between various causative agents and affected valve types (p < 0.001). Peripheral emboli were most common in episodes caused by S. aureus, infections of 2 native valves and the tricuspid valve, and least common in episodes caused by coagulase-negative staphylococci and in PVE. The occurrence of peripheral emboli was significantly associated with a vegetation detected on echocardiography, and with IVDU.
There were significant differences in the development of heart failure between the various microorganisms as causative agents and between the infected valve sites. Heart failure was most common in episodes caused by S. pneumoniae and in infection of 2 native valves, and least common in episodes caused by viridans streptococci and in tricuspid valve endocarditis. Heart failure was significantly associated with the age ?65 years.
The factors predicting in-hospital and 1-year mortality are presented in table 4. Age < 64 years significantly predicted a favourable outcome within 1 year from admission but not during the index hospitalisation. Infection of 2 native valves significantly predicted both in-hospital and 1-year mortality. The presence of a major criterion or vegetation on echocardiography significantly predicted mortality within 1 year from admission, but not during the index hospitalisation. The occurrence of neurological complications, peripheral emboli, or heart failure significantly predicted both in-hospital and 1-year mortality.
There was a significant trend between the level of CRP on admission and both short-term and 1-year outcome (table 4). In the trend analysis of association, it was found that an increment of 50 mg/l of CRP on admission was associated with a 1.33-fold hazard for in-hospital death (HR 1.33, 95% CI 1.06 to 1.68; p = 0.015) and a 1.24-fold hazard for death within 1 year from admission (HR 1.24, 95% CI 1.06 to 1.46; p = 0.009). In a similar analysis, corresponding to every increment of 100 mg/L on admission, the hazard for in-hospital death was 1.78-fold (HR 1.78, 95% CI 1.12 to 2.82; p = 0.015), and the hazard for 1-year death was 1.54-fold (HR 1.54, 95% CI 1.12 to 2.12; p = 0.009). ESR level ?50 mm/h, WBC count ?10 ? 109/l, or serum creatinine value ?100 ?mol/l on admission did not significantly predict in-hospital or 1-year mortality (table 4).
Among the surgically treated patients, the hazard for in-hospital death for the patients with CRP values ?100 mg/l on admission was 6.85-fold as compared to those with CRP values < 100 mg/l on admission (HR 6.85, 95% CI 1.51 to 30.95; p = 0.013). Among the conservatively treated patients, no significant association was observed between in-hospital mortality and the level of CRP on admission (p = 0.181). When analysed separately for the surgically and conservatively treated patients, no association was observed between the level of ESR on admission and in-hospital mortality (p values > 0.468).
The factors predicting the requirement for in-hospital and 1-year surgery are presented in table 5. Male sex and age < 64 years significantly predicted a need for surgery at both of these time points, as did the development of heart failure or the presence of a major criterion or vegetation on echocardiography. Peripheral emboli predicted a need for in-hospital surgery, while S. pneumoniae as the causative agent or infection of 2 native valves predicted a need for surgery within 1 year from admission.
Patients with CRP values ?100 mg/l on admission tended to require surgery during the index hospitalisation more commonly than those with lower CRP values, but the difference was not significant (p = 0.063). In the patients who had ESR values ?50 mm/h on admission, the hazard for in-hospital and 1-year surgery decreased to less than 50% as compared to those with lower ESR values (table 5).
Previous studies have defined various clinical and laboratory findings, which have prognostic significance in patients treated for infective endocarditis [5,8-12,18]. These studies have shown that the outcome of endocarditis may be associated with a number of clinical variables, e.g. age or underlying diseases of the patient, development of complications, echocardiographic findings, laboratory parameters of inflammation, and the virulence of the causative microorganisms. However, some inconsistencies between the results from different hospitals are evident. At least to some extent, this may be due to differences between the institutions or patient populations studied, or even between environmental or genetic factors. We sought to define the prognostic significance of some of the conventional risk predictors in patients treated for infective endocarditis in a Finnish teaching hospital.
Of the laboratory parameters of inflammation, the level of CRP on admission was most prominently associated with the outcome of endocarditis throughout the study period, the prognosis being significantly worse in the patients with high CRP values. Illustratively, in the patients who had CRP values ?100 mg/l on admission, the hazard ratio for in-hospital death was 2.9-fold and the hazard ratio for 1-year death was 3.9-fold as compared to the patients with lower CRP values (table 4). We are not aware of any previous study focusing on the level of the first CRP value as a prognostic sign in infective endocarditis, although Wallace et al.  have shown that in-hospital and 6-month mortalities were not affected by an abnormal or normal CRP value within 48 hours of admission. Instead, these authors found that mortality was strongly associated with abnormal WBC counts or serum creatinine concentrations. In our patients, elevated WBC counts on admission did not predict a poor outcome, but there was a tendency for a higher mortality in the patients with elevated serum creatinine concentrations. This probably reflected the worse general condition in these patients.
In many previous studies, S. aureus as the causative agent has been associated with an adverse outcome [9,11,19-23]. For example, in a recent study of Cabell et al. , S. aureus endocarditis had a 1.5-fold increase in the risk of death over 1 year as compared to the patients with endocarditis due to other pathogens. Also in the present study, there was a tendency for a higher mortality in S. aureus endocarditis as compared to the rest of the cases excluding S. pneumoniae endocarditis, but the association was significant only at 3 months. In another recent study , S. aureus did not confer a worse prognosis than other microorganisms. The authors assumed that this unconventional finding might have been due to the fact that among their patients with S. aureus endocarditis there was a high incidence of tricuspid valve involvement in which no deaths occurred. Consistently in our series, 20 of the 75 cases of S. aureus endocarditis were in patients with IVDU. Of these patients, 15 had tricuspid valve endocarditis with no mortality. We believe that this may have contributed to the fact that in the present study, the outcome of S. aureus endocarditis was not significantly worse than the outcome of endocarditis caused by other microorganisms. The high mortality rate of 45.5% in our patients with pneumococcal endocarditis is in line with previous findings , demonstrating the aggressive and destructive course of this disease.
Due to conflicting results of even the recent studies, the relation between survival and echocardiographic findings in infective endocarditis remains controversial. In their comprehensive study on risk classification for mortality, Hasbun et al.  found that the presence of a vegetation was not associated with increased 6-month mortality of endocarditis. Correspondingly, in a recent series of Chu et al.  echocardiographic findings were not predictive of in-hospital mortality. It is notable that in these two studies, the vegetation size and mobility were not analysed. Quite the opposite, there are many other studies showing that certain echocardiographic findings are significantly associated with mortality. In a prospective multicentre study, Thuny et al.  found that vegetation length was a strong predictor of 1-year mortality. When studying patients with aortic or mitral valve endocarditis, Cabell et al.  showed that vegetation size was a predictor of mortality at 30 days and 1 year. Further, in right-sided endocarditis in drug users, size of vegetation >2 cm proved a major prognostic factor of in-hospital mortality . In another recent series , a visible vegetation on echocardiography significantly influenced 6-month mortality, but not in-hospital mortality. Our results are in good correlation with many of these findings, since at 3 and 6 months, and 1 year, mortality of the patients with a vegetation on echocardiography was significantly higher than mortality of the patients without a vegetation. A visible vegetation increased the hazard for death within 1 year to 2.6-fold (table 4). Regrettably, the size and mobility of vegetations were not recorded in the present study.
The role of echocardiography in predicting embolic events has also been disputable, although recent studies suggest that vegetations, and especially certain characteristics of vegetations, are associated with a greater stroke rate . In this respect, our results are different, since a visible vegetation on echocardiography significantly predicted only peripheral emboli, not cerebral emboli or other neurological complications.
In our patients, heart failure was the complication, which was most significantly associated with an adverse outcome during the index hospitalisation and up to 1 year from admission. This corroborates other studies, which have found heart failure to be a major risk factor for mortality in endocarditis [11,27]. Also neurological complications and peripheral emboli significantly predicted both in-hospital and 1-year mortality. These findings compare with many previous reports [5,12]. Among the underlying diseases, diabetes has been shown to be associated with a higher mortality rate . The results of the present study do not corroborate this finding, as mortality in our patients was not dependent of diabetes, or of any other underlying conditions assessed.
Assessment of the role of cardiac surgery as a prognostic factor is very complicated. Patients may not be operated on because they are critically ill while some patients undergo cardiac surgery only because they have large vegetations. In the present study, mortality was somewhat higher for the surgically treated patients than for the patients treated conservatively. This finding is evidently due to a more severe disease with valve destructions in the patients who underwent surgery. The severity of the disease in these surgically treated patients is illustrated e.g. by their having a higher frequency of complications of endocarditis. The association between the requirement for surgery and heart failure was highly significant and, in addition, peripheral emboli were more common in patients who needed surgical treatment, although the association was significant only at the time point of 3 months. Also, these patients had a somewhat higher frequency of neurological complications than those treated conservatively. It is of note that all of these complications were shown to significantly predict mortality in our patients.
Although infective endocarditis is an uncommon disease, the long study period of 25 years made it possible for us to include a considerable number of patients with endocarditis. It is of concern, however, that during such a long period of time, there may have been changes in several aspects of diagnostic and therapeutic management of endocarditis. This is evidently one limitation of the present study.
Some of the factors (e.g. heart failure, neurological complications, peripheral emboli) predicting a poor prognosis and/or need for surgery in association with endocarditis were the same as observed in previous studies, while some other previously established poor prognostic factors (diabetes, elevated WBC counts) were not present in our patient population. A new finding was that high CRP values on admission significantly predicted both short-term and 1-year mortality in endocarditis.
The author(s) declare that they have no competing interests.
All of the authors contributed substantially to the study. MH collected the data. MH and PK designed the study and wrote the original version of the manuscript. HH, SM, TS, EE and JN contributed to evaluation of data and provided critical comments for the manuscript. HH and SM performed the statistical analyses. All authors read and approved the final version of the manuscript.
The pre-publication history for this paper can be accessed here:
|Nissen H,Nielsen PF,Frederiksen M,Helleberg C,Nielsen JS. Native valve infective endocarditis in the general population: a 10-year survey of the clinical picture during the 1980sEur Heart J 1992;13:872–877. [pmid: 1644074]|
|Van der Meer JTM,Thompson J,Valkenburg HA,Michel MF. Epidemiology of bacterial endocarditis in the Netherlands. I. Patient characteristicsArch Intern Med 1992;152:1863–1868. [pmid: 1520052] [doi: 10.1001/archinte.152.9.1863]|
|Watanakunakorn C,Burkert T. Infective endocarditis at a large community teaching hospital, 1980?1990. A review of 210 episodesMedicine (Baltimore) 1993;72:90–102. [pmid: 8479327]|
|Delahaye F,Goulet V,Lacassin F,Ecochard R,Selton-Suty C,Hoen B,Etienne J,Brian?on S,Leport C. Characteristics of infective endocarditis in France 1991. A 1-year surveyEur Heart J 1995;16:394–401. [pmid: 7789383]|
|Netzer ROM,Zollinger E,Seiler C,Cerny A. Infective endocarditis: clinical spectrum, presentation and outcome. An analysis of 212 cases 1980?1995Heart 2000;84:25–30. [pmid: 10862581] [doi: 10.1136/heart.84.1.25]|
|Hoen B,Alla F,Selton-Suty C,B?guinot I,Bouvet A,Brian?on S,Casalta JP,Danchin N,Delahaye F,Etienne J,Le Moing V,Leport C,Mainardi JL,Ruimy R,Vandenesch F. Changing profile of infective endocarditis. Results of a 1-year survey in FranceJAMA 2002;288:75–81. [pmid: 12090865] [doi: 10.1001/jama.288.1.75]|
|Tornos MP,Olona M,Permanyer-Miralda G,Almirante B,Evangelista A,Soler-Soler J. Is the clinical spectrum and prognosis of native valve infective endocarditis in non-addicts changing?Eur Heart J 1995;16:1686–1691. [pmid: 8881865]|
|Delahaye F,Ecochard R,de Gevigney G,Barjhoux C,Malquarti V,Saradarian W,Delaye J. The long term prognosis of infective endocarditisEur Heart J 1995;16:48–54. [pmid: 7671924]|
|Cabell CH,Jollis JG,Peterson GE,Corey GR,Anderson DJ,Sexton DJ,Woods CW,Reller LB,Ryan T,Fowler VG. Changing patient characteristics and the effect on mortality in endocarditisArch Intern Med 2002;162:90–94. [pmid: 11784225] [doi: 10.1001/archinte.162.1.90]|
|Wallace SM,Walton BI,Kharbanda RK,Hardy R,Wilson AP,Swanton RH. Mortality from infective endocarditis: clinical predictors of outcomeHeart 2002;88:53–60. [pmid: 12067945] [doi: 10.1136/heart.88.1.53]|
|Hasbun R,Vikram HR,Barakat LA,Buenconsejo J,Quagliarello VJ. Complicated left-sided native valve endocarditis in adults. Risk classification for mortalityJAMA 2003;289:1933–1940. [pmid: 12697795] [doi: 10.1001/jama.289.15.1933]|
|Chu VH,Cabell CH,Benjamin DK,Kuniholm EF,Fowler VG,Engemann J,Sexton DJ,Corey GR,Wang A. Early predictors of in-hospital death in infective endocarditisCirculation 2004;109:1745–1749. [pmid: 15037538] [doi: 10.1161/01.CIR.0000124719.61827.7F]|
|Heiro M,Nikoskelainen J,Hartiala JJ,Saraste MK,Kotilainen PM. Diagnosis of infective endocarditis. Sensitivity of the Duke vs von Reyn criteriaArch Intern Med 1998;158:18–24. [pmid: 9437374] [doi: 10.1001/archinte.158.1.18]|
|Heiro M,Nikoskelainen J,Engblom E,Kotilainen E,Marttila RJ,Kotilainen P. Neurologic manifestations of infective endocarditis. A 17-year experience in a teaching hospital in FinlandArch Intern Med 2000;160:2781–2787. [pmid: 11025788] [doi: 10.1001/archinte.160.18.2781]|
|Heiro M,Helenius H,Sundell J,Koskinen P,Engblom E,Nikoskelainen J,Kotilainen P. Utility of serum C-reactive protein in assessing the outcome of infective endocarditisEur Heart J 2005;26:1873–1881. [pmid: 15855194] [doi: 10.1093/eurheartj/ehi277]|
|Heiro M,Helenius H,M?kil? S,Savunen T,Engblom E,Nikoskelainen J,Kotilainen P. Infective endocarditis in a Finnish teaching hospital. A study on 326 episodes treated during 1980?2004Heart 2006;92:1457–1462. [pmid: 16644858] [doi: 10.1136/hrt.2005.084715]|
|Durack DT,Lukes AS,Bright DK,the Duke Endocarditis ServiceNew criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findingsAm J Med 1994;96:200–209. [pmid: 8154507] [doi: 10.1016/0002-9343(94)90143-0]|
|Thuny F,Disalvo G,Belliard O,Avierinos JF,Pergola V,Rosenberg V,Casalta JP,Gouvernet J,Derumeaux G,Iarussi D,Ambrosi P,Calabro R,Riberi A,Collart F,Metras D,Lepidi H,Raoult D,Harle JR,Weiller PJ,Cohen A,Habib G. Risk of embolism and death in infective endocarditis: prognostic value of echocardiography. A prospective multicenter studyCirculation 2005;112:69–75. [pmid: 15983252] [doi: 10.1161/CIRCULATIONAHA.104.493155]|
|Sanabria TJ,Alpert JS,Goldberg R,Pape LA,Cheeseman SH. Increasing frequency of staphylococcal infective endocarditis. Experience at a university hospital, 1981 through 1988Arch Intern Med 1990;150:1305–1309. [pmid: 2353863] [doi: 10.1001/archinte.150.6.1305]|
|Fernandez-Guerrero ML,Verdejo C,Azofra J,Azofra J,de Gorgolas M. Hospital-acquired infectious endocarditis not associated with cardiac surgery: an emerging problemClin Infect Dis 1995;20:16–23. [pmid: 7727642]|
|R?der BL,Wandall DA,Frimodt-M?ller N,Espersen F,Skinhoj P,Rosdahl VT. Clinical features of Staphylococcus aureus endocarditis: a 10-year experience in DenmarkArch Intern Med 1999;159:462–469. [pmid: 10074954] [doi: 10.1001/archinte.159.5.462]|
|Miro JM,Anguera I,Cabell CH,Chen AY,Stafford JA,Corey GR,Olaison L,Eykyn S,Hoen B,Abrutyn E,Raoult D,Bayer A,Fowler VG Jr,International Collaboration on Endocarditis Merged Database Study GroupStaphylococcus aureus native valve infective endocarditis: Report of 566 episodes from the International Collaboration on endocarditis merged databaseClin Infect Dis 2005;41:507–514. [pmid: 16028160] [doi: 10.1086/431979]|
|Nadji G,R?madi JP,Coviaux F,Ali Mirode A,Brahim A,Enriquez-Sarano M,Tribouilloy C. Comparison of clinical and morphological characteristics of Staphylococcus aureus endocarditis with endocarditis caused by other pathogensHeart 2005;91:932–937. [pmid: 15958364] [doi: 10.1136/hrt.2004.042648]|
|Aronin SI,Mukherjee SK,West JC,Cooney EL. Review of pneumococcal endocarditis in adults in the penicillin eraClin Infect Dis 1998;26:165–171. [pmid: 9455526]|
|Cabell CH,Pond KK,Peterson GE,Durack DT,Corey GR,Anderson DJ,Ryan T,Lukes AS,Sexton DJ. The risk of stroke and death in patients with aortic and mitral valve endocarditisAm Heart J 2001;142:75–80. [pmid: 11431660] [doi: 10.1067/mhj.2001.115790]|
|Martin-D?vila P,Navas E,Fort?n J,Moya JL,Cobo J,Pintado V,Quereda C,Jimenez-Mena M,Moreno S. Analysis of mortality and risk factors associated with native valve endocarditis in drug users: The importance of vegetation sizeAm Heart J 2005;150:1099–1106. [pmid: 16291005] [doi: 10.1016/j.ahj.2005.02.009]|
|Siddiq S,Missri J,Silverman DI. Endocarditis in an urban hospital in the 1990sArch Intern Med 1996;156:2454–2458. [pmid: 8944738] [doi: 10.1001/archinte.156.21.2454]|
Association between cumulative mortality within 1 year and patient characteristics in 326 episodes of infective endocarditis
|Mortality during n (%)|
|N||In-hospitala||p value||3 months||p value||6 months||p value||1 year||p value|
|?Male||234||35 (15.0)||34 (14.7)||38 (16.5)||39 (17.0)|
|?Female||92||11 (12.0)||9 (9.9)||11 (12.1)||14 (15.7)|
|?18?64 years||209||23 (11.0)||21 (10.2)||24 (11.6)||25 (12.1)|
|??65 years||117||23 (19.7)||22 (19.0)||25 (21.8)||28 (24.9)|
|?Staphylococcus aureus||75||14 (18.7)||14 (18.9)||15 (20.3)||15 (20.3)|
|?CoNSc||31||6 (19.4)||6 (19.4)||6 (19.4)||6 (19.4)|
|?Viridans streptococci||67||10 (14.9)||8 (12.0)||11 (16.8)||12 (18.4)|
|?Enterococcus faecalis||25||2 (8.0)||2 (8.0)||2 (8.0)||3 (12.8)|
|?Streptococcus pneumoniae||11||5 (45.5)||5 (45.5)||5 (45.5)||5 (45.5)|
|?Other||28||2 (7.1)||1 (3.6)||2 (7.3)||2 (7.3)|
|?Negative||89||7 (7.9)||7 (8.1)||8 (9.2)||10.(11.6)|
|?Aortic||113||16 (14.2)||15 (13.4)||16 (14.4)||17 (15.4)|
|?Mitral||96||6 (6.3)||7 (7.3)||8 (8.4)||9 (9.5)|
|?Tricuspid||18||2 (11.1)||1 (5.9)||2 (11.8)||2 (11.8)|
|?Two native valves||32||14 (43.8)||13 (40.6)||14 (43.8)||15 (46.9)|
|?Prosthetic valve(s)||67||8 (11.9)||7 (10.6)||9 (13.7)||10 (15.3)|
|??Yes||221||37 (16.7)||34 (15.6)||40 (18.4)||44 (20.4)|
|??No||105||9 (8.6)||9 (8.7)||9 (8.7)||9 (8.7)|
|??Yes||198||36 (18.2)||32 (16.3)||38 (19.5)||42 (21.7)|
|??No||128||10 (7.8)||11 (8.7)||11 (8.7)||11 (8.7)|
|??Yes||86||21 (24.4)||19 (22.5)||21 (24.9)||22 (26.1)|
|??No||240||25 (10.4)||24 (10.1)||28 (11.8)||31 (13.2)|
|??Yes||102||22 (22.0)||18 (18.3)||22 (22.6)||23 (23.7)|
|??No||224||24 (10.6)||25 (11.1)||27 (12.1)||30 (13.5)|
|??Yes||178||41 (23.0)||38 (21.8)||44 (25.5)||47 (27.5)|
|??No||148||5 (3.4)||5 (3.4)||5 (3.4)||6 (4.1)|
|??Yes||89||15 (16.9)||13 (14.7)||15 (17.0)||16 (18.2)|
|??No||237||31 (13.1)||30 (12.8)||34 (14.6)||37 (16.0)|
|CRP on admissione||0.005||<0.001||<0.001||<0.001|
|??100 mg/l||148||28 (18.9)||29 (19.7)||31 (21.1)||34 (23.3)|
|?< 100 mg/l||124||8 (6.5)||5 (4.1)||8 (6.6)||8 (6.6)|
|Creatinine on admissionf||0.075||0.017||0.052||0.160|
|??100 ?mol/l||108||28 (18.9)||19 (17.7)||19 (17.7)||19 (17.7)|
|?< 100 ?mol/l||174||17 (9.8)||15 (8.7)||18 (10.4)||22 (12.8)|
aMean (SD) duration of in-hospital treatment was 55 (33), range 4 to 272 days; bp values for overall group differences; ccoagulase-negative staphylococci; dwithin 3 months from admission; edata available for 272 episodes; fdata available for 282 episodes
Cumulative proportion of patients needing surgery within 1 year and clinical characteristics in 326 episodes of infective endocarditis
|Need for surgery n (%)|
|N||In-hospitala||p value||3 months||p value||6 months||p value||1 year||p value|
|?Male||234||74 (31.6)||78 (35.0)||83 (37.6)||88 (40.2)|
|?Female||92||15 (16.3)||16 (18.2)||19 (22.1)||21 (24.8)|
|?18?64 years||209||73 (34.9)||77 (38.1)||84 (41.9)||88 (44.1)|
|??65 years||117||16 (13.7)||17 (15.4)||18 (16.5)||21 (20.2)|
|?Staphylococcus aureus||75||17 (22.7)||19 (28.6)||19 (28.6)||20 (30.4)|
|?CoNSc||31||9 (29.0)||9 (30.6)||9 (30.6)||9 (30.6)|
|?Viridans streptococci||67||20 (22.9)||20 (31.1)||25 (39.9)||28 (45.4)|
|?Enterococcus faecalis||25||4 (160)||4 (17.4)||4 (17.4)||4 (17.4)|
|?Streptococcus pneumoniae||11||4 (36.4)||5 (49.1)||6 (61.8)||6 (61.8)|
|?Other||28||8 (28.6)||8 (28.6)||10 (36.8)||10 (36.8)|
|?Negative||89||27 (30.0)||29 (33.1)||29 (33.1)||32.(37.0)|
|?Aortic||113||44 (38.9)||45 (42.4)||46 (43.5)||48 (45.8)|
|?Mitral||96||11 (11.5)||14 (15.1)||20 (21.9)||24 (26.9)|
|?Tricuspid||18||0 (0)||0 (0)||0 (0)||0 (0)|
|?Two native v alves||32||15 (46.9)||15 (50.5)||16 (55.5)||17 (60.4)|
|?Prosthetic valve(s)||67||19 (28.4)||20 (30.9)||20 (30.9)||20 (30.9)|
|??Yes||221||77 (34.8)||78 (37.1)||86 (41.6)||89 (43.3)|
|??No||105||12 (11.4)||16 (16.0)||16 (16.0)||20 (20.5)|
|??Yes||198||66 (33.3)||66 (35.3)||74 (40.3)||77 (42.3)|
|??No||128||23 (18.0)||28 (22.7)||28 (22.7)||32 (26.3)|
|??Yes||86||28 (32.6)||28 (35.3)||30 (38.3)||33 (43.0)|
|??No||240||61 (25.4)||66 (28.5)||72 (31.5)||76 (33.5)|
|??Yes||102||36 (36.0)||36 (38.7)||37 (40.1)||39 (42.8)|
|??No||224||53 (23.5)||58 (26.7)||65 (30.2)||70 (32.9)|
|??Yes||178||64 (36.0)||67 (40.7)||70 (43.1)||73 (45.6)|
|??No||148||25 (16.9)||27(18.5)||32 (22.0)||36 (25.0)|
|Intravenous drug use||0.170||0.074||0.045||0.030|
|??Yes||25||3 (12.0)||3 (12.6)||3 (12.6)||3 (12.6)|
|??No||301||86 (28.6)||91 (31.7)||99 (35.0)||106 (39.7)|
|ESR on admissione||0.005||0.004||0.010||0.003|
|??50 mm/h||99||18 (18.2)||19 (19.8)||22 (23.2)||23 (24.5)|
|?< 50 mm/h||93||31 (33.3)||35 (39.6)||36 (40.8)||40 (46.0)|
aMean (SD) duration of in-hospital treatment was 55 (33), range 4 to 272 days; bp values for overall group differences; ccoagulase-negative staphylococci; dwithin 3 months from admission; edata on erythrocyte sedimentation rate available for 192 episodes
Association between in-hospitala complications and clinical characteristics in 326 episodes of infective endocarditis
|N||Neurologic events n (%)||p value||Cerebral emboli n (%)||p value||Peripheral emboli n (%)||p value||Heart failure n (%)||p value|
|?Male||234||65 (27.8)||38 (16.2)||77 (32.9)||125 (53.4)|
|?Female||92||21 (22.8)||10 (10.9)||25 (27.2)||53 (57.6)|
|?18?64 years||209||57 (27.3)||31 (14.8)||63 (30.1)||105 (50.2)|
|??65 years||117||29 (24.8)||17 (14.5)||39 (33.3)||73 (62.4)|
|?Staphylococcus aureus||75||26 (34.7)||14 (18.7)||39 (52.0)||37 (49.3)|
|?CoNSc||31||7 (22.6)||5 (16.1)||3 (9.7)||20 (64.5)|
|?Viridans streptococci||67||18 (26.9)||15 (22.4)||20 (29.9)||28 (41.8)|
|?Enterococcus faecalis||25||6 (24.0)||2 (8.0)||7 (28.0)||17 (68.0)|
|?Streptococcus pneumoniae||11||7 (63.6)||2 (18.2)||3 (27.3)||10 (90.9)|
|?Other pathogens||28||6 (21.4)||2 (7.1)||9 (32.1)||14 (50.0)|
|?Negative||89||16 (18.0)||8 (9.0)||21 (23.6)||52.(58.4)|
|?Aortic||113||30 (26.6)||16 (14.2)||43 (38.1)||64 (56.6)|
|?Mitral||96||25 (26.0)||17 (17.7)||24 (25.0)||46 (47.9)|
|?Tricuspid||18||3 (16.7)||0 (0)||10 (55.6)||4 (22.2)|
|?Two native valves||32||14 (43.8)||8 (25.0)||18 (56.3)||25 (78.1)|
|?Prosthetic valve(s)||67||19 (20.9)||7 (10.5)||7 (10.5)||39 (58.2)|
|??Yes||221||61 (27.6)||33 (14.9)||77 (34.8)||129 (58.4)|
|??No||105||25 (23.8)||15 (14.3)||25 (23.8)||49 (46.7)|
|??Yes||198||58 (29.3)||32 (16.2)||76 (38.4)||116 (58.6)|
|??No||128||28 (21.9)||16 (12.5)||26 (20.37)||62 (48.4)|
|Intravenous drug use||1.0||1.0||0.012||0.146|
|??Yes||25||6 (24.0)||3 (12.0)||14 (56.0)||10 (40.0)|
|??No||301||80 (26.6)||45 (15.0)||88 (29.2)||168 (55.8)|
aMean (SD) duration of in-hospital treatment was 55 (33), range 4 to 272 days; bp values for overall group differences; ccoagulase-negative staphylococci
Factors predicting in-hospitala mortality and mortality within 1 year from admission in 326 episodes of infective endocarditis
|Hazard ratio for in-hospital death||95% CI||p value||Hazard ratio for death within 1 year||95% CI||p value|
|?Two native valves||3.55||1.49?8.47||3.75||1 68?8.34|
|Serum CRP on admission||0.008||<0.001|
|?< 100 mg/l||1||1|
aMean (SD) duration of in-hospital treatment was 55 (33), range 4 to 272 days; bp values for overall group differences; ccoagulase-negative staphylococci; dwithin 3 months from admission
Factors predicting in-hospitala surgery and surgery within 1 year from admission
|Hazard ratio for in-hospital surgery||95% CI||p value||Hazard ratio for surgery within 1 year||95% CI||p value|
|?18?64 years||3.03||1.76 ? 5.21||2.57||1.59 ? 4.13|
|?Male||2.30||1.32 ? 4.02||1.83||1.14 ? 2.95|
|?CoNSc||1.17||0.52 ? 2.63||1.07||0.49 ? 2.36|
|?Viridans streptococci||1.55||0.81 ? 2.96||1.56||0.88 ? 2.77|
|?Enterococcus faecalis||0.59||0.20 ? 1.76||0.53||0.18 ? 1.56|
|?Streptococcus pneumoniae||1.59||0.53 ? 4.76||2.67||1.07 ? 6.65|
|?Other pathogens||1.28||0.55 ? 2.97||1.30||0.61?2.77|
|?Culture negative||1.38||0.75 ? 2.54||1.34||0.77 ?2.35|
|?Aortic||1.41||0.82 ? 2.42||1.47||0.87?2.48|
|?Mitral||0.30||0.14 ? 0.65||0.67||0.37?1.22|
|?Two native valves||1.77||0.90 ? 3.49||2.22||1.16?4.25|
|??Yes||2.99||1.63 ? 5.50||2.57||1.58 ? 4.18|
|??Yes||1.71||1.06 ? 2.76||1.76||1.17 ? 2.66|
|??Yes||1.22||0.77 ? 1.94||1.32||0.88 ? 1.99|
|??Yes||6.12||3.97 ? 9.42||1.37||0.93 ? 2.03|
|??Yes||2.26||1.42 ? 3.59||2.27||1.52 ? 3.39|
|Serum CRP on admission|
|?< 100 mg/l||1||1|
|ESRf on admission|
|?< 50 mm/h||1||1||0.28?0.78||0.004|
aMean (SD) duration of in-hospital treatment was 55 (33), range 4 to 272 days; bp values for overall group differences; ccoagulase-negative staphylococci; dNA; not applicable, 0 number of cases; ewithin 3 months from admission; ferythrocyte sedimentation rate
Previous Document: Genotypic variation in genome-wide transcription profiles induced by insect feeding: Brassica olerac...
Next Document: Migraine aura or transient ischemic attacks? A five-year follow-up case-control study of women with ...