Document Detail


Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age.
MedLine Citation:
PMID:  21056288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis of this study is that a folate-deficient diet (FD) has a greater effect on cholinergic system in the peripheral nervous system than in the brain, and that this effect escalates with age. It was tested by comparing choline and acetylcholine levels in male Sprague Dawley rats fed either control or folate-deficient diets for 10 weeks, starting at age 4 weeks (the young group) or 9 months (the adult group). Folate-deficient diet consumption resulted in depletion of plasma folate in both age groups. In young folate-deficient rats, liver and lung choline levels were significantly lower than those in the respective controls. No other significant effects of FD on choline and acetylcholine metabolism were found in young rats. In adult rats, FD consumption markedly decreased choline levels in the liver, kidneys, and heart; furthermore, choline levels in the cortex and striatum were moderately elevated, although hippocampal choline levels were not affected. Acetylcholine levels were higher in the heart, cortex, and striatum but lower in the hippocampus in adult folate-deficient rats, as compared to controls. Higher acetylcholine levels in the striatum in adult folate-deficient rats were also associated with higher dopamine release in the striatal slices. Thus, both age groups showed higher cholinergic metabolic sensitivity to FD in the peripheral nervous system than in the brain. However, compensatory abilities appeared to be better in the young group, implicating the adult group as a preferred model for further investigation of folate-choline-acetylcholine interactions and their role in brain plasticity and cognitive functions.
Authors:
Natalia A Crivello; Jan K Blusztajn; James A Joseph; Barbara Shukitt-Hale; Donald E Smith
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nutrition research (New York, N.Y.)     Volume:  30     ISSN:  1879-0739     ISO Abbreviation:  Nutr Res     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-02-09     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8303331     Medline TA:  Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-30     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism*
Aging / metabolism
Animals
Brain / metabolism*
Choline / metabolism*
Choline Deficiency / metabolism*
Diet
Dopamine / metabolism
Folic Acid / administration & dosage,  blood
Folic Acid Deficiency / metabolism*
Kidney / metabolism
Liver / metabolism
Lung / metabolism
Male
Myocardium / metabolism
Peripheral Nervous System / metabolism*
Rats
Rats, Sprague-Dawley
Vitamin B Complex / administration & dosage,  blood
Grant Support
ID/Acronym/Agency:
P01 AG009525/AG/NIA NIH HHS; P01 AG009525-17/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 935E97BOY8/Folic Acid; N91BDP6H0X/Choline; N9YNS0M02X/Acetylcholine; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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