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Short-term modulation of the exercise ventilatory response in younger and older women.
MedLine Citation:
PMID:  21890003     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The exercise ventilatory response (EVR; defined as the slope of the relationship between ventilation and CO(2) production) is reversibly augmented within a single exercise trial with increased respiratory dead space (DS) in both younger (Wood, H.E., Mitchell, G.S., Babb, T.G., 2008. Short-term modulation of the exercise ventilatory response in young men. J. Appl. Physiol. 104, 244-252) and older (FASEB J 2008, 22:1233.9) men. The neural mechanism accounting for this augmentation is known as short-term modulation (STM) of the EVR. Since the effects of female sex hormones on STM are unknown, we examined the capacity for STM in healthy adult women of two age groups; nine younger (29±3yrs, eumenorrheic) and seven older (69±3yrs, postmenopausal) women were studied at rest and during cycle exercise (10W, 30W; not randomized) in control conditions and with added external DS (200mL, 400mL; randomized). Within groups, the main effects of DS and work rate on EVR were analyzed with a two-way repeated measures ANOVA; EVR comparisons between groups were made with unpaired t-tests. In both groups, EVR increased progressively with increasing DS volume (e.g. at 10W 31±4 and 35±6 in control, 40±11 and 40±6 with 200mL, 48±12 and 49±11 with 400mL DS in younger and older women, respectively). In younger women, the effects of DS on EVR differed between work rates (significant interaction, p<0.05), although this was not the case for older women. In both groups, [Formula: see text] regulation was similar between DS and control; hence, increased EVR was not due to altered chemoreceptor feedback from rest to exercise. EVR with and without added DS did not differ between age groups. We conclude that the capacity for STM of the EVR with added DS is similar in healthy younger and older women.
Authors:
Helen E Wood; Gordon S Mitchell; Tony G Babb
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-27
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, United States; University of Texas Southwestern Medical Center-Dallas, Dallas, TX, United States.
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