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Short-term melatonin consumption protects the heart of obese rats independent of body weight change and visceral adiposity.
MedLine Citation:
PMID:  25187154     Owner:  NLM     Status:  Publisher    
Chronic melatonin treatment has been shown to prevent the harmful effects of diet-induced obesity and reduce myocardial susceptibility to ischaemia-reperfusion injury (IRI). However, the exact mechanism whereby it exerts its beneficial actions on the heart in obesity/insulin resistance remains unknown. Herein, we investigated the effects of relatively short-term melatonin treatment on the heart in a rat model of diet-induced obesity. Control and diet-induced obese Wistar rats (fed a high calorie diet for 20 weeks) were each subdivided into 3 groups receiving drinking water with or without melatonin (4mg/kg/day) for the last 6 or 3 weeks of experimentation. A number of isolated hearts were perfused in the working mode, subjected to regional or global ischaemia-reperfusion; others were non-perfused. Metabolic parameters, myocardial infarct sizes, baseline and post-ischaemic activation of PKB/Akt, ERK42/44, GSK-3β and STAT-3 were determined. Diet-induced obesity caused increases in body weight gain, visceral adiposity, fasting blood glucose, serum insulin and triglyceride levels with a concomitant cardiac hypertrophy, large post-ischaemic myocardial infarct sizes and a reduced cardiac output. Melatonin treatment (3 and 6 weeks) decreased serum insulin levels and the HOMA-index (p<0.05) with no effect on weight gain (after 3 weeks), visceral adiposity, serum triglyceride and glucose levels. It increased serum adiponectin levels, reduced myocardial infarct sizes in both groups and activated baseline myocardial STAT-3 and PKB/Akt, ERK42/44 and GSK-3β during reperfusion. Overall, short-term melatonin administration to obese/insulin resistant rats reduced insulin resistance and protected the heart against ex vivo myocardial IRI independently of body weight change and visceral adiposity. This article is protected by copyright. All rights reserved.
Frederic Nduhirabandi; Barbara Huisamen; Hans Strijdom; Dee Blackhurst; Amanda Lochner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-4
Journal Detail:
Title:  Journal of pineal research     Volume:  -     ISSN:  1600-079X     ISO Abbreviation:  J. Pineal Res.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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