| Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan. | |
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MedLine Citation:
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PMID: 19440812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Endoluminal gastroplication (ELGP) was the first endoscopic therapy for gastroesophageal reflux disease (GERD). Data on the long-term outcomes, including the plication status and data from Asian populations, are limited. The aim of this study was to evaluate the short-term and long-term effectiveness and safety of ELGP for GERD in the Japanese population. METHODS: This was an open-label, prospective, multicenter trial of ELGP. Forty-eight patients with GERD were enrolled. The procedure involved placing circumferential plications 1-2 cm below the GE junction using the EndoCinch system. Outcome measurements were improvement of heartburn, medication use, endoscopic Los Angeles grade, durability of plications, 24-h esophageal acid exposure, esophageal manometry, and frequency of adverse events. RESULTS: During the 24-month follow-up, the rate of complete resolution of heartburn ranged from 54 to 66%, the rate of discontinuation or reduction of PPI/H2RA use ranged from 65 to 76%, and the rate of endoscopic classification to grade O ranged from 66 to 81%. The status with more than one plication remaining was associated with higher rates of improvement of heartburn, PPI/H2RA use, and endoscopic findings as compared with those associated with the loss of all plications. A modest decrease of the esophageal acid exposure level, but no change of the manometric parameters, was observed after ELGP. No serious adverse events were observed. CONCLUSIONS: In this 24-month follow-up study conducted in Japanese subjects, ELGP was found to be effective in about 60% of patients with GERD, and the procedure was safe. |
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Authors:
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Soji Ozawa; Koichiro Kumai; Kazuhide Higuchi; Tetsuo Arakawa; Mototsugu Kato; Masahiro Asaka; Natsuya Katada; Hiroyuki Kuwano; Masaki Kitajima |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study Date: 2009-05-14 |
Journal Detail:
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Title: Journal of gastroenterology Volume: 44 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2009-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
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Languages: eng Pagination: 675-84 Citation Subset: IM |
Affiliation:
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Department of General and Gastrointestinal Surgery, School of Medicine, Fujita Health University, 3-6-10 Otobashi, Nakagawa-ku, Nagoya, Aichi, 454-8509, Japan. sozawa@fujita-hu.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Endoscopy, Digestive System Female Follow-Up Studies Gastroesophageal Reflux / surgery* Heartburn / diagnosis Humans Japan Male Middle Aged Surgical Procedures, Minimally Invasive* Treatment Outcome |
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