Document Detail

Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan.
MedLine Citation:
PMID:  19440812     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Endoluminal gastroplication (ELGP) was the first endoscopic therapy for gastroesophageal reflux disease (GERD). Data on the long-term outcomes, including the plication status and data from Asian populations, are limited. The aim of this study was to evaluate the short-term and long-term effectiveness and safety of ELGP for GERD in the Japanese population. METHODS: This was an open-label, prospective, multicenter trial of ELGP. Forty-eight patients with GERD were enrolled. The procedure involved placing circumferential plications 1-2 cm below the GE junction using the EndoCinch system. Outcome measurements were improvement of heartburn, medication use, endoscopic Los Angeles grade, durability of plications, 24-h esophageal acid exposure, esophageal manometry, and frequency of adverse events. RESULTS: During the 24-month follow-up, the rate of complete resolution of heartburn ranged from 54 to 66%, the rate of discontinuation or reduction of PPI/H2RA use ranged from 65 to 76%, and the rate of endoscopic classification to grade O ranged from 66 to 81%. The status with more than one plication remaining was associated with higher rates of improvement of heartburn, PPI/H2RA use, and endoscopic findings as compared with those associated with the loss of all plications. A modest decrease of the esophageal acid exposure level, but no change of the manometric parameters, was observed after ELGP. No serious adverse events were observed. CONCLUSIONS: In this 24-month follow-up study conducted in Japanese subjects, ELGP was found to be effective in about 60% of patients with GERD, and the procedure was safe.
Soji Ozawa; Koichiro Kumai; Kazuhide Higuchi; Tetsuo Arakawa; Mototsugu Kato; Masahiro Asaka; Natsuya Katada; Hiroyuki Kuwano; Masaki Kitajima
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study     Date:  2009-05-14
Journal Detail:
Title:  Journal of gastroenterology     Volume:  44     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-10     Completed Date:  2009-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  675-84     Citation Subset:  IM    
Department of General and Gastrointestinal Surgery, School of Medicine, Fujita Health University, 3-6-10 Otobashi, Nakagawa-ku, Nagoya, Aichi, 454-8509, Japan.
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MeSH Terms
Aged, 80 and over
Endoscopy, Digestive System
Follow-Up Studies
Gastroesophageal Reflux / surgery*
Heartburn / diagnosis
Middle Aged
Surgical Procedures, Minimally Invasive*
Treatment Outcome

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