Document Detail

Short-term and long-term mortality associated with ventricular arrhythmia in patients hospitalized with acute coronary syndrome: findings from the Gulf RACE registry-2.
MedLine Citation:
PMID:  23363987     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Ventricular arrhythmia (VA) in the setting of acute coronary syndrome (ACS) carries an ominous prognosis; however, long-term prognosis associated with VA in ACS in the Middle East is unknown. Accordingly, we sought to assess the incidence, in-hospital outcomes, and 1-year mortality of in-hospital VA in patients with ACS. METHODS AND RESULTS: The Second Gulf Registry of Acute Coronary Events (Gulf RACE-2) is a multinational observational study of patients with ACS, which enrolled 7930 patients. Of these, 333 (4.2%) developed VA during hospitalization. Patients with VA were significantly older (mean age 58.3 vs. 56.8 years), and had a significantly higher rate of prior stroke/transient ischemic attack (7.5 vs. 4.2%), smoking (36.6 vs. 35.6%), congestive heart failure (11.0 vs. 6.5%), and peripheral artery disease (6.5 vs. 1.7%), compared with patients without VA. They had significantly less diabetes mellitus (35.4 vs. 40.3%), hypertension (43.2 vs. 47.9%), percutaneous coronary intervention (6.1 vs. 9.4%), and dyslipidemia (22.4 vs. 38.2%). The adjusted odds ratios for in-hospital, 30-day, and 1-year mortality in VA complicating all ACS were 25.8, 11.1, and 7.3; ST-elevation myocardial infarctions were 18.3, 11.7, and 6.3; and unstable angina and non-ST elevation myocardial infarctions were 47.4, 10.3, and 18.7, respectively (all P<0.001). CONCLUSION: In-hospital VA in patients with ACS with and without ST elevation was associated with significantly higher in-hospital, 30-day, and 1-year mortality. Noticeably higher long-term mortality among Middle Eastern patients with ACS having VA compared with other reports requires further study and warrants immediate attention.
Ahmad Hersi; Khalid F Alhabib; Alawi A Alsheikh-Ali; Kadhim Sulaiman; Hussam F Alfaleh; Shukri Alsaif; Wael Al-Mahmeed; Nidal Asaad; Haitham Amin; Ahmed Al-Motarreb; Jassim Al Suwaidi
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Publication Detail:
Journal Detail:
Title:  Coronary artery disease     Volume:  24     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  160-164     Citation Subset:  -    
aDepartment of Cardiac Sciences, College of Medicine, King Saud University, Riyadh bDepartment of Cardiology, Saud Al-Babtain Cardiac Center, Dammam, Kingdom of Saudi Arabia cDepartment of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates dDepartment of Cardiology, Royal Hospital, Muscat, Oman eDepartment of Cardiology and Cardiovascular Surgery, Hamad Medical Corporation (HMC), Doha, Qatar fDepartment of Cardiology, Mohammed Bin Khalifa Cardiac Center, Manama, Bahrain gDepartment of Medicine, Faculty of Medicine, Sana'a University, Sana'a, Yemen.
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