Document Detail


Short-term and long-term effects of Norplant-2 on plasma lipoproteins and glucose tolerance.
MedLine Citation:
PMID:  1908177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-five women using the levonorgestrel-containing contraceptive implant, Norplant-2, were studied longitudinally, to see the effects on lipid profile, glucose tolerance and hepatic transaminases with short-term (12 weeks) and long-term (18 to 24 months) use of Norplant-2 [corrected]. Total lipids, cholesterol, phospholipids, triglycerides and their subfractions were evaluated. There was a significant increase in LDL-cholesterol after 12 weeks of use (p less than 0.05), which did not persist at 18-24 months follow-up. The HDL-cholesterol, HDL/LDL-cholesterol ratio, phospholipids, other lipid fractions, hepatic transaminases and glucose tolerance did not alter significantly following short-term or long-term use of Norplant-2.
Authors:
Y Bala; G I Dhall; S Majumdar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in contraception : the official journal of the Society for the Advancement of Contraception     Volume:  7     ISSN:  0267-4874     ISO Abbreviation:  Adv Contracept     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-09-13     Completed Date:  1991-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607435     Medline TA:  Adv Contracept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alanine Transaminase / analysis
Aspartate Aminotransferases / analysis
Blood Glucose / drug effects*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cholesterol, VLDL / blood
Contraceptive Agents, Female / pharmacology*
Female
Humans
Levonorgestrel
Lipoproteins / blood*
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Liver / enzymology
Longitudinal Studies
Norgestrel / pharmacology*
Transaminases / metabolism
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Contraceptive Agents, Female; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 6533-00-2/Norgestrel; 797-63-7/Levonorgestrel; EC 2.6.1.-/Transaminases; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase
Comments/Corrections
Erratum In:
Adv Contracept 1992 Mar;8(1):50

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