| Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology? | |
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MedLine Citation:
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PMID: 20128787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Isotretinoin is an effective treatment for acne vulgaris. However, it has numerous side-effects. It was previously reported that serum growth hormone (GH) levels decreased with isotretinoin treatment. OBJECTIVES: To analyse whether isotretinoin has any effects on insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP3) and GH levels. METHODS: Forty-seven patients aged 21.5 +/- 5.1 years (mean +/- SD) with acne vulgaris were included in this study. Isotretinoin therapy was initiated at a dose of 0.5-0.75 mg kg(-1) daily and then adjusted to 0.88 mg kg(-1) daily as maintenance dosage after 1 month. Screening for biochemical and hormonal parameters was performed just before initiation and after 3 months of isotretinoin treatment. RESULTS: IGF-1 and IGFBP3 levels decreased significantly after treatment (P < 0.01), while GH levels did not change. Post-treatment, significant increases were seen in aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, triglycerides and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (P < 0.0001) while high-density lipoprotein cholesterol levels were significantly decreased (P < 0.0001). CONCLUSIONS: Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association. |
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Authors:
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A S Karadag; D T Ertugrul; E Tutal; K O Akin |
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Publication Detail:
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Type: Journal Article Date: 2010-02-01 |
Journal Detail:
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Title: The British journal of dermatology Volume: 162 ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 798-802 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Keçiören Research and Training Hospital, 06290 Keçiören, Ankara, Turkey. drayserem@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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blood,
drug therapy* Adolescent Dermatologic Agents / therapeutic use* Female Human Growth Hormone / blood*, drug effects, physiology Humans Insulin-Like Growth Factor Binding Protein 3 / blood* Insulin-Like Growth Factor I / metabolism* Isotretinoin / therapeutic use* Male Reference Values Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Insulin-Like Growth Factor Binding Protein 3; 12629-01-5/Human Growth Hormone; 4759-48-2/Isotretinoin; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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