| Short-term intrathrombotic injection of ultrahigh-dose urokinase for treatment of iliac and femoropopliteal artery occlusions. | |
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MedLine Citation:
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PMID: 2147294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty-two patients with iliac and femoropopliteal artery occlusions were treated with direct intrathrombotic injection of ultrahigh-dose urokinase (10,000 IU/min). Occlusions ranged from 3 to 25 cm (average 13.3 cm) in length and the total urokinase dose from 120,000 to 1,410,000 IU (average 688,000 IU). The procedure was usually followed by balloon angioplasty to dilate the underlying stenoses. The initial recanalization rate was 96.9%, the two week patency rate 81.3%, and the cumulative one-year patency rate 66.3%. Complications associated with this procedure included three episodes of minimal bleeding, two distal embolisms, one local hematoma, and one low-grade fever. All were well controlled by palliative treatment. Results indicate that this procedure can provide rapid recanalization at a higher success rate and with fewer complications than previously reported. |
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Authors:
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M Terada; M Satoh; K Mitsuzane; Y Shioyoyama; M Tsuda; K Kishi; M Maeda; S Momura; R Yamada |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Radiation medicine Volume: 8 ISSN: 0288-2043 ISO Abbreviation: Radiat Med Publication Date: 1990 May-Jun |
Date Detail:
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Created Date: 1991-01-09 Completed Date: 1991-01-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8412264 Medline TA: Radiat Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Affiliation:
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Department of Radiology, Wakayama Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiography Angiography, Digital Subtraction Angioplasty, Balloon Combined Modality Therapy Female Femoral Artery / radiography Humans Iliac Artery / radiography Leg / blood supply* Male Middle Aged Popliteal Artery / radiography Recurrence Thromboembolism / drug therapy*, radiography, therapy Thrombolytic Therapy / methods* Urokinase-Type Plasminogen Activator / administration & dosage*, therapeutic use Vascular Patency |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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