| Short-term intra-arterial infusion of monocyte chemoattractant protein-1 results in sustained collateral artery growth. | |
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MedLine Citation:
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PMID: 17495259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monocyte chemoattractant protein-1 (MCP-1) is a stimulator of collateral artery growth and has been shown to increase collateral artery conductance in rabbits and pigs. The minimal infusion duration and the minimally effective dose of MCP-1 are currently unknown, as is the sustainability of the therapeutic effect over a longer observation period than tested before. MCP-1 was infused intra-arterially in pigs after unilateral femoral artery occlusion in different doses and infusion durations between 2 hours and 2 weeks. Two weeks after ligation, arterial conductance under maximal vasodilatation was measured. The long-term efficacy was investigated in 2 additional groups of animals after 6 weeks. Infusion with 2 microg/min of MCP-1 for 6 hours was sufficient to double arterial conductance, and arterial conductance after 6 weeks was still significantly increased. |
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Authors:
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Randolph W Seidler; Martin C Lenter; Brian D Guth; Henri Doods |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology and therapeutics Volume: 12 ISSN: 1074-2484 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-05-14 Completed Date: 2007-07-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 61-8 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA. rseidler@rdg.boehringer-ingelheim.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects*, growth & development, physiopathology CHO Cells Chemokine CCL2 / administration & dosage, genetics, pharmacology* Collateral Circulation / drug effects Cricetinae Cricetulus Disease Models, Animal Dose-Response Relationship, Drug Female Femoral Artery / surgery Humans Infusions, Intra-Arterial Ligation / adverse effects Male Peripheral Vascular Diseases / drug therapy*, etiology, physiopathology Receptors, CCR2 Receptors, Chemokine / genetics, physiology Recombinant Proteins / administration & dosage, pharmacology Swine Swine, Miniature Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/CCR2 protein, human; 0/Chemokine CCL2; 0/Receptors, CCR2; 0/Receptors, Chemokine; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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