Document Detail

Short-term inhibition of cardiac cellular autophagy by isoproterenol.
MedLine Citation:
PMID:  3443985     Owner:  NLM     Status:  MEDLINE    
It is shown in the present study by means of quantitative electron microscopy that the volume fraction of autophagic vacuoles is significantly reduced to about half the control value within a short time interval (about 10 min) after low dose administration of isoproterenol. The data suggest that stimulation of cardiac work is accompanied by an immediate anticatabolic reaction which can be assumed to represent an early contribution to the adaptative increase in myocardial mass known to result from long-term stimulation of cardiac work.
U Pfeifer; J Föhr; W Wilhelm; J Dämmrich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  19     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-05-04     Completed Date:  1988-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1179-84     Citation Subset:  IM    
Department of Pathology, University of Würzburg, Germany.
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MeSH Terms
Autophagy / drug effects*
Heart / drug effects*
Heart Ventricles / ultrastructure
Isoproterenol / pharmacology*
Phagocytosis / drug effects*
Time Factors
Reg. No./Substance:

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