Document Detail


Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats, utilization of stable isotopes and inductively-coupled plasma mass spectrometry technique.
MedLine Citation:
PMID:  10211056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amount of dietary trace elements absorbed from a meal depends, among other factors, on the quantities of certain minor plant constituents present in the meal. These substances can act as ligands and bind trace elements in the digestive tract in available or unavailable forms for absorption. The present study was designed to investigate the extent to which different polyphenols (PP) may influence Zn and Cu absorption in rats. Different PP of nutritional interest (chlorogenic acid, caffeic acid, catechin and rutin) were studied using meals extrinsically-labelled with stable isotopes 67Zn and 65Cu. Male Wistar rats were fed on a non-labelled semi-synthetic diet containing (mg/kg) 38 Fe, 35 Zn and 7.5 Cu for 8 d. PP were dissolved in dimethyl sulfoxide as the solvent and added to the meal at 1 g/kg during 3 d before isotope administration and until the end of the experiment (a further 3 d). The control group received the dimethyl sulfoxide only. After overnight food deprivation, rats were fed on the labelled test meals (4 g diet +0.1 mg 67Zn and 0.1 mg 65Cu) with 0.5 mg Dy as a faecal marker. Faeces and urine pools were collected for 3 d and analysed for 67Zn and 65Cu isotopic enrichment using the inductively-coupled plasma mass spectrometry technique. Zn absorption was significantly less in rats fed on chlorogenic acid or caffeic acid than in the control group. Catechin ingestion non-significantly inhibited 67Zn absorption. However, the PP studied were without effect on Cu absorption. The study illustrates the effect of metal-binding phenolic compounds on mineral nutrition in the rat, and the possible importance of the effects of different foods rich in these compounds on mineral absorption in man.
Authors:
C Coudray; C Bousset; J C Tressol; D Pépin; Y Rayssiguier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  80     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-27     Completed Date:  1999-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  575-84     Citation Subset:  IM    
Affiliation:
Centre de Recherche en Nutrition Humaine d'Auvergne, INRA de Clermont-Ferrand/Theix, Champanelle, France. charles.coudray@clermont.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / administration & dosage*
Caffeic Acids / administration & dosage*
Catechin / administration & dosage
Chlorogenic Acid / administration & dosage*
Copper / metabolism*
Feces / chemistry
Intestinal Absorption / drug effects*
Isotopes
Male
Mass Spectrometry
Rats
Rats, Wistar
Rutin / administration & dosage
Time Factors
Zinc / metabolism*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Caffeic Acids; 0/Isotopes; 153-18-4/Rutin; 154-23-4/Catechin; 327-97-9/Chlorogenic Acid; 331-39-5/caffeic acid; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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