Document Detail


Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease.
MedLine Citation:
PMID:  18245143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Interstitial lung disease (ILD) is characterised by exertional dyspnoea, exercise limitation and reduced quality of life. The role of exercise training in this diverse patient group is unclear. The aims of this study were to establish the safety of exercise training in ILD; its effects on exercise capacity, dyspnoea and quality of life; and whether patients with idiopathic pulmonary fibrosis (IPF) had similar responses to those with other types of ILD. METHODS: 57 subjects with ILD (34 IPF) were randomised to receive 8 weeks of supervised exercise training or weekly telephone support. The 6 min walk distance (6MWD), incremental exercise test, modified Medical Research Council (MRC) dyspnoea score and Chronic Respiratory Disease Questionnaire (CRDQ) were performed at baseline, following intervention and at 6 months. RESULTS: 80% of subjects completed the exercise programme and no adverse events were recorded. The 6MWD increased following training (mean difference to control 35 m, 95% CI 6 to 64 m). A significant reduction in MRC score was observed (0.7 points, 95% CI 0.1 to 1.3) along with improvements in dyspnoea (p = 0.04) and fatigue (p<0.01) on the CRDQ. There was no change in peak oxygen uptake; however, exercise training reduced heart rate at maximum isoworkload (p = 0.01). There were no significant differences in response between those with and without IPF. After 6 months there were no differences between the training and control group for any outcome variable. CONCLUSIONS: Exercise training improves exercise capacity and symptoms in patients with ILD, but these benefits are not sustained 6 months following intervention.
Authors:
A E Holland; C J Hill; M Conron; P Munro; C F McDonald
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-02-01
Journal Detail:
Title:  Thorax     Volume:  63     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-30     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  549-54     Citation Subset:  IM    
Affiliation:
Physiotherapy Department, Alfred Hospital, Commercial Rd, Melbourne, Australia 3004. a.holland@alfred.org.au
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00168285
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Dyspnea / etiology
Exercise Therapy / methods*
Exercise Tolerance / physiology*
Humans
Lung Diseases, Interstitial / rehabilitation*
Middle Aged
Quality of Life
Social Support
Telemedicine / methods
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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