Document Detail

Short-term hypoxia reduces arterial stiffness in healthy men.
MedLine Citation:
PMID:  18815804     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of hypoxia (80% arterial oxyhaemoglobin saturation for 20 min) and the accompanying changes in heart rate and blood pressure on two components of arterial stiffness in healthy men. Augmentation index (AIx) and time to reflection (Tr) representing measures of muscular artery and aortic stiffness, respectively, were continuously measured. At first, subjects were exposed to either hypoxia (n = 12) or room air (n = 5). During early hypoxia AIx increased by 6% before decreasing to baseline. After hypoxia AIx decreased by a further 6%. In contrast there was no change in Tr. Six subjects were then exposed to hypoxia following infusion with the nitric oxide (NO) synthase inhibitor NG-mono-methyl-L: -arginine (L-NMMA) or saline. During hypoxia AIx decreased by 12% following saline but increased by 14% after L-NMMA and Tr did not change. These findings suggest that hypoxia may induce NO-mediated vasodilatation of small muscular arteries but not the aorta.
Hima Vedam; Craig L Phillips; David Wang; David J Barnes; Jan A Hedner; Gunnar Unger; Ronald R Grunstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-25
Journal Detail:
Title:  European journal of applied physiology     Volume:  105     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Woolcock Institute of Medical Research, Sydney, NSW, 2050, Australia.
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MeSH Terms
Anoxia / physiopathology*
Arteries / physiopathology*
Blood Pressure / physiology
Heart Rate / physiology
Nitric Oxide / pharmacology
Vascular Resistance / physiology
Vasodilation / physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide

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