Document Detail

Short-term (-)-hydroxycitrate ingestion increases fat oxidation during exercise in athletes.
MedLine Citation:
PMID:  12171433     Owner:  NLM     Status:  MEDLINE    
(-)-Hydroxycitrate (HCA) is known to inhibit increasing malonyl CoA concentration during endurance exercise. Furthermore, a short-term administration of HCA enhances endurance exercise performance in mice. Therefore we investigated the short-term administration of HCA on the exercise performance of athletes. Subjects were administered 250 mg of HCA or placebo as a control (CON) for 5 d, after each time performing cycle ergometer exercise at 60% VO2max for 60 min followed by 80% VO2max until exhaustion. Blood was collected and expired gas samples analyzed at rest and every 15 min. The respiratory exchange ratio was significantly lower in the HCA trial than in the CON trial (p < 0.05). Fat oxidation was significantly increased by short-term administration of HCA, and carbohydrate oxidation was significantly decreased (p < 0.05) during exercise, presumably resulting in increasing the cycle ergometer exercise time to exhaustion after 1 h of 60% VO2max exercise (p < 0.05). These results suggest that a short-term administration of HCA enhances endurance performance with increasing fat oxidation, which spares glycogen utilization during moderate intensity exercise in athletes.
Kiwon Lim; Sungpil Ryu; Yasuyuki Ohishi; Itaru Watanabe; Hironori Tomi; Heajung Suh; Woong-Ki Lee; Taedong Kwon
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  48     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-08-12     Completed Date:  2003-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  128-33     Citation Subset:  IM    
Institute of Elderly Health, Kangnam-gu, Seoul, Korea.
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MeSH Terms
Adipose Tissue / metabolism*
Blood Gas Analysis
Citrates / administration & dosage,  pharmacology*
Exercise / physiology*
Exercise Test
Fatty Acids, Nonesterified / blood
Lipolysis / drug effects*
Oxygen Consumption / drug effects
Physical Endurance / drug effects*
Respiration / drug effects
Reg. No./Substance:
0/Citrates; 0/Fatty Acids, Nonesterified; 6205-14-7/hydroxycitric acid

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