Document Detail

Short-term heart rate variability in healthy young adults: the Cardiovascular Risk in Young Finns Study.
MedLine Citation:
PMID:  19019739     Owner:  NLM     Status:  MEDLINE    
Reduced short-term heart rate variability (HRV) is a risk factor for cardiovascular morbidity and total mortality. The reference values of short-term HRV indices in healthy young adults are unknown. To investigate age and sex differences in HRV and to generate reference values of short-term recordings, we examined 1780 healthy subjects aged 24 to 39 years. Both frequency and time domain HRV indices were computed. Indices included; low frequency (LF), high frequency (HF) and total components of spectral-HRV, the square root of mean squared differences of R-R-intervals and SD of normal R-R-intervals. Deep breathing test was performed and the mean ratio of R-R-intervals and the mean difference in instantaneous heart rate during breathing cycle were analyzed. Reproducibility of these indices was studied in 43 subjects. Aging and higher heart rate were inversely associated with all HRV indices (all p values <0.0001). Women had higher HF and lower LF compared to men (both p<0.0001). Women had higher resting heart rate (70 vs. 65 bpm, p<0.0001). The reproducibility of HRV indices and deep breathing test were good (CV 5.3-13.9%). We conclude that age, sex and heart rate needs to be considered when evaluating HRV indices and when generating reference values. Because of good reproducibility the short-term indices of HRV and deep breathing test can be used in clinical work.
Tuomas Koskinen; Mika Kähönen; Antti Jula; Tomi Laitinen; Liisa Keltikangas-Järvinen; Jorma Viikari; Ilkka Välimäki; Olli T Raitakari
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-18
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  145     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
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MeSH Terms
Age Factors
Cardiovascular Physiological Processes
Electrocardiography / methods
Finland / epidemiology
Follow-Up Studies
Heart Rate / physiology*
Respiratory Mechanics / physiology
Risk Factors
Time Factors
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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