Document Detail

Short-term forecasting of life-threatening cardiac arrhythmias based on symbolic dynamics and finite-time growth rates.
MedLine Citation:
PMID:  11046317     Owner:  NLM     Status:  MEDLINE    
Ventricular tachycardia or fibrillation (VT-VF) as fatal cardiac arrhythmias are the main factors triggering sudden cardiac death. The objective of this study is to find early signs of sustained VT-VF in patients with an implanted cardioverter-defibrillator (ICD). These devices are able to safeguard patients by returning their hearts to a normal rhythm via strong defibrillatory shocks; additionally, they store the 1000 beat-to-beat intervals immediately before the onset of a life-threatening arrhythmia. We study these 1000 beat-to-beat intervals of 17 chronic heart failure ICD patients before the onset of a life-threatening arrhythmia and at a control time, i.e., without a VT-VF event. To characterize these rather short data sets, we calculate heart rate variability parameters from the time and frequency domain, from symbolic dynamics as well as the finite-time growth rates. We find that neither the time nor the frequency domain parameters show significant differences between the VT-VF and the control time series. However, two parameters from symbolic dynamics as well as the finite-time growth rates discriminate significantly both groups. These findings could be of importance in algorithms for next generation ICD's to improve the diagnostics and therapy of VT-VF.
N Wessel; C Ziehmann; J Kurths; U Meyerfeldt; A Schirdewan; A Voss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics     Volume:  61     ISSN:  1063-651X     ISO Abbreviation:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2001-01-23     Completed Date:  2001-01-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9887340     Medline TA:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-9     Citation Subset:  IM    
University of Applied Sciences Jena, Tatzendpromenade 1b, 07745 Jena, Germany.
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MeSH Terms
Arrhythmias, Cardiac / diagnosis*,  physiopathology,  therapy
Biophysical Phenomena
Defibrillators, Implantable
Heart Failure / physiopathology,  therapy
Heart Rate
Models, Cardiovascular
Nonlinear Dynamics
Tachycardia, Ventricular / diagnosis,  physiopathology,  therapy
Ventricular Fibrillation / diagnosis,  physiopathology,  therapy

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