Document Detail

Short-term follow-up results of drug-eluting stenting in premature coronary artery disease patients with multiple atherosclerotic risk factors.
MedLine Citation:
PMID:  18653396     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Premature coronary artery disease (CAD) is a special entity with a strong link to familial hypercholesterolemia, family history of premature CAD, or multiple coexistent atherosclerotic risk factors. Drug-eluting stenting (DES), including paclitaxel-eluting stenting (PES) and sirolimus-eluting stenting (SES), has been proven to have a lower restenotic rate. However, to date, few studies have investigated the clinical and angiographic results of DES in premature CAD patients. METHODS: Between February 2004 and October 2005, premature CAD patients, defined as those younger than 50 years of age, who were treated with DES in our medical center were all retrospectively enrolled. Their baseline clinical characteristics, clinical outcome and angiographic follow-up results were analyzed. RESULTS: A total of 26 patients (M/F: 23/3) were enrolled, with a mean age of 44+/-6 years (range, 24-50 years). Conventional atherosclerotic risk factors were prevalent in this study group, including diabetes mellitus (35%), hypertension (35%), hyperlipidemia (54%) and smoking (73%). Moreover, there was 1 homozygous and 1 heterozygous familial hypercholesterolemia case in our study group. In terms of angiographic results, there were 40 target lesions in 34 target vessels. Forty DES (39 PES, 1 SES) were implanted with a median stent diameter of 3 mm and median length of 24 mm. The clinical follow-up was counted up to May 2006, with a mean follow-up duration of 540+/-168 days; 11 (42%) patients had a second angiogram during the follow-up period (200+/-98 days after DES). None of the patients had target lesion revascularization (TLR). In addition, there was no difference in TLR or stent thrombosis between patients with or without acute coronary syndrome. CONCLUSION: Based on our single-center experience, DES had good short-term follow-up results for a premature CAD group with diverse and multiple atherosclerotic risk factors.
Ming-Hsiung Wang; Wen-Lieng Lee; Kuo-Yang Wang; Yu-Cheng Hsieh; Tsun-Jui Liu; I-Hsiang Lin; Wei-Wen Lin; Chih-Tai Ting; Kae-Woei Liang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Chinese Medical Association : JCMA     Volume:  71     ISSN:  1726-4901     ISO Abbreviation:  J Chin Med Assoc     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101174817     Medline TA:  J Chin Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
Cardiovascular Center, Taichung Veterans General Hospital, and Department of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
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MeSH Terms
Arteriosclerosis / etiology*
Coronary Disease / therapy*
Drug-Eluting Stents*
Follow-Up Studies
Middle Aged
Retrospective Studies
Risk Factors
Treatment Outcome

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