Document Detail


Short-term exposure to high dietary cholesterol in early life: arterial changes and response after normalization of plasma cholesterol.
MedLine Citation:
PMID:  2750698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated serum cholesterol is an established risk factor for the development of atherosclerosis but the effect of high dietary cholesterol in early life on subsequent arterial response to atherogenic diet in adult life is unknown. Weanling rabbits were exposed for 6 wk to a diet containing 0.25% cholesterol, allowed to recover for 9 wk (at least 3 wk after normalization of plasma cholesterol), and subsequently rechallenged with cholesterol to determine atherogenic response. Enhanced activity of acyl-CoA-cholesterol-acyl-transferase in aorta induced by cholesterol feeding persisted even after normalization of serum cholesterol. When rechallenged with cholesterol for 3 mo, these animals displayed significantly (p less than 0.05) increased development of aortic atherosclerosis and accumulation of cholesterol esters when compared with control animals. Exposure to cholesterol in early life appears to cause persistent changes in cholesterol ester synthetic enzyme activity in aorta after normalization of plasma cholesterol and these residual effects might increase aortic response to subsequent cholesterol challenge in adult life.
Authors:
M T Subbiah; J D Sprinkle; Z Rymaszewski; R L Yunker
Related Documents :
438658 - Effect of diosgenin on lipid metabolism in rats.
2809398 - Contrasting effects of lovastatin and cholestyramine on low-density lipoprotein cholest...
15669758 - Lipids rich in phosphatidylethanolamine from natural gas-utilizing bacteria reduce plas...
7097348 - Early cholesterol feeding: are there long-term effects in the rat?
23798518 - Effects of dietary soybean oil on pig growth performance, retention of protein, lipids,...
2487068 - Cholesterol microlithiasis: bacteriology, gallbladder bile and stone composition.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  50     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-14     Completed Date:  1989-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine and Pathology, University of Cincinnati Medical Center, OH.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / drug effects*,  metabolism,  pathology
Arteriosclerosis / enzymology,  etiology*,  pathology
Cholesterol / blood*
Cholesterol Esters / analysis
Cholesterol, Dietary / administration & dosage*,  adverse effects
Rabbits
Sterol O-Acyltransferase / analysis
Grant Support
ID/Acronym/Agency:
HL-24071/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Cholesterol, Dietary; 57-88-5/Cholesterol; EC 2.3.1.26/Sterol O-Acyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adipogenic activity in sera from obese children before and after weight reduction.
Next Document:  A theoretical basis for increasing current estimates of the amino acid requirements in adult man, wi...