Document Detail

Short-term exposure to high dietary cholesterol in early life: arterial changes and response after normalization of plasma cholesterol.
MedLine Citation:
PMID:  2750698     Owner:  NLM     Status:  MEDLINE    
Elevated serum cholesterol is an established risk factor for the development of atherosclerosis but the effect of high dietary cholesterol in early life on subsequent arterial response to atherogenic diet in adult life is unknown. Weanling rabbits were exposed for 6 wk to a diet containing 0.25% cholesterol, allowed to recover for 9 wk (at least 3 wk after normalization of plasma cholesterol), and subsequently rechallenged with cholesterol to determine atherogenic response. Enhanced activity of acyl-CoA-cholesterol-acyl-transferase in aorta induced by cholesterol feeding persisted even after normalization of serum cholesterol. When rechallenged with cholesterol for 3 mo, these animals displayed significantly (p less than 0.05) increased development of aortic atherosclerosis and accumulation of cholesterol esters when compared with control animals. Exposure to cholesterol in early life appears to cause persistent changes in cholesterol ester synthetic enzyme activity in aorta after normalization of plasma cholesterol and these residual effects might increase aortic response to subsequent cholesterol challenge in adult life.
M T Subbiah; J D Sprinkle; Z Rymaszewski; R L Yunker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  50     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-14     Completed Date:  1989-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  AIM; IM    
Department of Internal Medicine and Pathology, University of Cincinnati Medical Center, OH.
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MeSH Terms
Aorta / drug effects*,  metabolism,  pathology
Arteriosclerosis / enzymology,  etiology*,  pathology
Cholesterol / blood*
Cholesterol Esters / analysis
Cholesterol, Dietary / administration & dosage*,  adverse effects
Sterol O-Acyltransferase / analysis
Grant Support
Reg. No./Substance:
0/Cholesterol Esters; 0/Cholesterol, Dietary; 57-88-5/Cholesterol; EC O-Acyltransferase

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