Document Detail


Short-term exercise training improves insulin sensitivity but does not inhibit inflammatory pathways in immune cells from insulin-resistant subjects.
MedLine Citation:
PMID:  23671849     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background. Exercise has an anti-inflammatory effect against, and immune cells play critical roles in the development, of insulin resistance and atherosclerotic vascular disease (AVD). Thus, the goal of this study was to determine whether exercise improves insulin sensitivity in insulin-resistant subjects by downregulating proinflammatory signaling in immune cells. Methods. Seventeen lean, 8 obese nondiabetic, and 11 obese type 2 diabetic individuals underwent an aerobic exercise program for 15 days and an insulin clamp before and after exercise. Peripheral mononuclear cells (PMNC) were obtained for determination of Toll-like receptor (TLR) 2 and 4 protein content and mitogen-activated protein kinase phosphorylation. Results. Compared with that in lean individuals, TLR4 protein content was increased by 4.2-fold in diabetic subjects. This increase in TLR4 content was accompanied by a 3.0-fold increase in extracellular signal-regulated kinase (ERK) phosphorylation. Exercise improved insulin sensitivity in the lean, obese, and type 2 diabetes groups. However, exercise did not affect TLR content or ERK phosphorylation. Conclusions. TLR4 content and ERK phosphorylation are increased in PMNC of type 2 diabetic individuals. While exercise improves insulin sensitivity, this effect is not related to changes in TLR2/TLR4 content or ERK phosphorylation in PMNC of type 2 diabetic individuals.
Authors:
Sara M Reyna; Puntip Tantiwong; Eugenio Cersosimo; Ralph A Defronzo; Apiradee Sriwijitkamol; Nicolas Musi
Related Documents :
22333369 - Usefulness of non-contact mapping for radiofrequency catheter ablation of inappropriate...
23667629 - Acute exercise induces fgf21 expression in mice and in healthy humans.
24231599 - Patients with type 1 diabetes oxidize fat at a greater rate than age- and sex-matched c...
8629539 - Prescribing exercise for health: a simple framework for primary care.
12604869 - Health-related quality of life of japanese patients with chronic heart failure: assessm...
469609 - Strategies for increasing employees' level of exercise and physical fitness.
4365809 - A statistical analysis of the release of acetylcholine at newly formed synapses in stri...
12734789 - Post-exercise increase of lipid oxidation after a moderate exercise bout in untrained h...
17986569 - Effect of a home exercise program based on tai chi in patients with end-stage renal dis...
Publication Detail:
Type:  Journal Article     Date:  2013-03-13
Journal Detail:
Title:  Journal of diabetes research     Volume:  2013     ISSN:  2314-6745     ISO Abbreviation:  J Diabetes Res     Publication Date:  2013  
Date Detail:
Created Date:  2013-05-14     Completed Date:  2013-05-15     Revised Date:  2013-05-17    
Medline Journal Info:
Nlm Unique ID:  101605237     Medline TA:  J Diabetes Res     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  107805     Citation Subset:  -    
Affiliation:
Medical Research Division, Regional Academic Health Center, 1214 W. Schunior Street, Edinburg, TX 78541, USA ; Diabetes Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA ; Texas Diabetes Institute, 701 S. Zarzamora, San Antonio, TX 78207, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protection effect of endomorphins on advanced glycation end products induced injury in endothelial c...
Next Document:  The hypocholesterolemic effect of germinated brown rice involves the upregulation of the apolipoprot...