| Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients. | |
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MedLine Citation:
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PMID: 19189080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil. METHODS: Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe(1), ProRe(2)), with the same sedation targets. RESULTS: With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe(1): respectively, 3.3 +/- 3.0 versus 8.9 +/- 6.1 and 7.47 +/- 5.05 versus 16.3 +/- 11.4 min. During SevAn the PaCO(2) and minute ventilation increased. Hemodynamics was stable between ProRe(1) and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits. CONCLUSIONS: Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions. |
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Authors:
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Maurizio Migliari; Giacomo Bellani; Roberto Rona; Stefano Isgrò; Beatrice Vergnano; Tommaso Mauri; Nicolò Patroniti; Antonio Pesenti; Giuseppe Foti |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-03 |
Journal Detail:
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Title: Intensive care medicine Volume: 35 ISSN: 1432-1238 ISO Abbreviation: Intensive Care Med Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1240-6 Citation Subset: IM |
Affiliation:
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Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza (MI), Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aged Anesthesiology / instrumentation* Anesthetics, Inhalation / administration & dosage, pharmacology* Critical Illness* Cross-Over Studies Deep Sedation / methods* Feasibility Studies Female Humans Intensive Care Units Male Methyl Ethers / administration & dosage, pharmacology* Middle Aged Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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