Document Detail

Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients.
MedLine Citation:
PMID:  19189080     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil. METHODS: Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe(1), ProRe(2)), with the same sedation targets. RESULTS: With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe(1): respectively, 3.3 +/- 3.0 versus 8.9 +/- 6.1 and 7.47 +/- 5.05 versus 16.3 +/- 11.4 min. During SevAn the PaCO(2) and minute ventilation increased. Hemodynamics was stable between ProRe(1) and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits. CONCLUSIONS: Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions.
Maurizio Migliari; Giacomo Bellani; Roberto Rona; Stefano Isgrò; Beatrice Vergnano; Tommaso Mauri; Nicolò Patroniti; Antonio Pesenti; Giuseppe Foti
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-03
Journal Detail:
Title:  Intensive care medicine     Volume:  35     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1240-6     Citation Subset:  IM    
Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza (MI), Italy.
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MeSH Terms
Administration, Inhalation
Anesthesiology / instrumentation*
Anesthetics, Inhalation / administration & dosage,  pharmacology*
Critical Illness*
Cross-Over Studies
Deep Sedation / methods*
Feasibility Studies
Intensive Care Units
Methyl Ethers / administration & dosage,  pharmacology*
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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