Document Detail


Short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients.
MedLine Citation:
PMID:  15340108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyze the short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients. RESEARCH METHODS AND PROCEDURES: Five metabolic cardiovascular risk factors (blood glucose, blood pressure, total cholesterol, high-density lipoprotein (HDL)-cholesterol, and triglycerides) were determined before and 15.3 +/- 2.1 months after laparoscopic gastric banding in 650 morbidly obese patients. Global cardiovascular risk was calculated according to the Prospective Cardiovascular Münster (PROCAM) scoring system. RESULTS: Mean weight loss was 22.7 +/- 20.4 kg. Normalization of the metabolic alteration was observed in 67.3% of patients with diabetes, 38.3% of patients with hypercholesterolemia, 72.5% of patients with low HDL-cholesterol, 72.3% of patients with hypertriglyceridemia, and 46.7% of patients with hypertension. PROCAM score fell from 31.4 +/- 11.6 to 28.0 +/- 12.0 points (p < 0.001). The modifications of total cholesterol and blood pressure were unrelated to percentage weight loss. Percentage weight loss was significantly related to the reductions of fasting blood glucose, triglyceride level, and the PROCAM score and to the increase of HDL-cholesterol concentrations observed after surgery. However, the strength of these four relationships was generally low. The variations of HDL-cholesterol concentrations and blood pressure levels were more influenced by actual energy balance than by the extent of weight loss. DISCUSSION: Weight loss observed in the first 12 to 18 months after gastric banding was associated with a significant improvement of single cardiovascular risk factors and global risk. On the other hand, the extent of weight loss was poorly related to the magnitude of improvement in cardiovascular risk.
Authors:
Luca Busetto; Giuseppe Sergi; Giuliano Enzi; Gianni Segato; Francesco De Marchi; Mirto Foletto; Maurizio De Luca; Sabrina Pigozzo; Franco Favretti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obesity research     Volume:  12     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-01     Completed Date:  2004-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1256-63     Citation Subset:  IM    
Affiliation:
Obesity Unit, Department of Medical and Surgical Sciences, Unviersity of Padova, Padova, Italy. luca.busetto@unipd.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / analysis
Blood Pressure
Body Mass Index
Cardiovascular Diseases* / prevention & control
Cholesterol / blood
Cholesterol, HDL / blood
Female
Gastroplasty
Humans
Laparoscopy
Male
Middle Aged
Obesity, Morbid / complications*,  physiopathology,  surgery*
Risk Factors
Triglycerides / blood
Weight Loss*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Triglycerides; 57-88-5/Cholesterol

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