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Short-term effects and teratogenicity of heptanol on embryos of Xenopus laevis.
MedLine Citation:
PMID:  21782688     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study examined teratogenic and short-term effects of heptanol on Xenopus embryos. Embryos were exposed for 5h to 2.5mM heptanol at different developmental stages. Teratogenic effects were found in embryos treated from cleavage to early neurula stages. Other heptanol concentrations, shorter exposure time, and the effect of temperature were also assayed. Short-term effects of hepatanol exposure were studied during cleavage and all treated blastulae showed cell separation with delaminated blastomeres inside the blastocel. Disruption of cell adhesion in addition to the uncoupling effect could account for heptanol teratogenicity.
Authors:
Eva Olmedo; Lidia Bardia; Jordi Domingo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  15     ISSN:  1382-6689     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2011-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  -    
Affiliation:
Department of Cell Biology and Pathology, Universtat de Barcelona, Campus de Bellvitge, Feixa Llarga, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
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