Document Detail

Short-term effects of systemic antibiotics during periodontal healing.
MedLine Citation:
PMID:  20305865     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the short-term effects of nonsurgical therapy (scaling and root planing, SRP) on the subgingival microbiota in chronic (CP) and aggressive (AP) periodontal disease. METHOD AND MATERIALS: Ninety-seven CP and AP subjects underwent full-mouth SRP on 2 consecutive days. AP patients were randomly assigned to either receive systemic metronidazole plus amoxicillin (AP+AB) or were treated mechanically alone (AP). Pathogens were identified with 16S rRNA oligodeoxynucleotide probes and dot-blot hybridization before and at days 2, 3, 4, 7, 10, and 21 of healing. CP subjects were treated by scaling and root planing along with placebo tablets. RESULTS: Initially, AP cell counts were 69.9- (Porphyromonas gingivalis), 10.2- (Aggregatibacter actinomycetemcomitans), 5.7- (Tannerella forsythia), and 3.3-fold (Prevotella intermedia) enhanced compared to CP cell counts. Following SRP, immediate elimination occurred in single individuals of all three treatment groups at day 2. After SRP plus antibiotic therapy (AP+AB), the prevalence scores dropped beyond the levels of AP and CP, beginning at day 7, and remained low until day 21 (P =or< .05). Clinical healing statistically benefited from SRP with no differences among the three treatment groups. CONCLUSION: Nonsurgical therapy resulted in both a suppression and early elimination of single taxa immediately after completion of active treatment. Systemic antibiotics significantly accelerate the suppression of the periodontal microflora, but have limited effect on the elimination of target isolates during healing.
Rainer Buchmann; Georg Conrads; Anton Sculean
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Quintessence international (Berlin, Germany : 1985)     Volume:  41     ISSN:  1936-7163     ISO Abbreviation:  Quintessence Int     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342677     Medline TA:  Quintessence Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  303-12     Citation Subset:  D    
Division of Periodontology, Medical Faculty, University of D?sseldorf, Dortmund, Germany.
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MeSH Terms
Actinobacillus Infections / therapy
Actinobacillus actinomycetemcomitans / isolation & purification
Aggressive Periodontitis / microbiology,  therapy*
Amoxicillin / therapeutic use*
Anti-Bacterial Agents / therapeutic use*
Anti-Infective Agents / therapeutic use*
Bacteroidaceae Infections / therapy
Bacteroides / classification
Bacteroides Infections / therapy
Chronic Periodontitis / microbiology,  therapy*
Colony Count, Microbial
Combined Modality Therapy
Dental Scaling*
Drug Combinations
Follow-Up Studies
Metronidazole / therapeutic use*
Middle Aged
Periodontal Attachment Loss / microbiology,  therapy
Periodontal Index
Periodontal Pocket / microbiology,  therapy
Porphyromonas gingivalis / isolation & purification
Prevotella intermedia / isolation & purification
Root Planing*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Drug Combinations; 0/Placebos; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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