| Short-term effects of systemic antibiotics during periodontal healing. | |
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MedLine Citation:
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PMID: 20305865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the short-term effects of nonsurgical therapy (scaling and root planing, SRP) on the subgingival microbiota in chronic (CP) and aggressive (AP) periodontal disease. METHOD AND MATERIALS: Ninety-seven CP and AP subjects underwent full-mouth SRP on 2 consecutive days. AP patients were randomly assigned to either receive systemic metronidazole plus amoxicillin (AP+AB) or were treated mechanically alone (AP). Pathogens were identified with 16S rRNA oligodeoxynucleotide probes and dot-blot hybridization before and at days 2, 3, 4, 7, 10, and 21 of healing. CP subjects were treated by scaling and root planing along with placebo tablets. RESULTS: Initially, AP cell counts were 69.9- (Porphyromonas gingivalis), 10.2- (Aggregatibacter actinomycetemcomitans), 5.7- (Tannerella forsythia), and 3.3-fold (Prevotella intermedia) enhanced compared to CP cell counts. Following SRP, immediate elimination occurred in single individuals of all three treatment groups at day 2. After SRP plus antibiotic therapy (AP+AB), the prevalence scores dropped beyond the levels of AP and CP, beginning at day 7, and remained low until day 21 (P =or< .05). Clinical healing statistically benefited from SRP with no differences among the three treatment groups. CONCLUSION: Nonsurgical therapy resulted in both a suppression and early elimination of single taxa immediately after completion of active treatment. Systemic antibiotics significantly accelerate the suppression of the periodontal microflora, but have limited effect on the elimination of target isolates during healing. |
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Authors:
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Rainer Buchmann; Georg Conrads; Anton Sculean |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Quintessence international (Berlin, Germany : 1985) Volume: 41 ISSN: 1936-7163 ISO Abbreviation: Quintessence Int Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0342677 Medline TA: Quintessence Int Country: Germany |
Other Details:
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Languages: eng Pagination: 303-12 Citation Subset: D |
Affiliation:
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Division of Periodontology, Medical Faculty, University of D?sseldorf, Dortmund, Germany. rainer.buchmann@med.uni-dueseldorf.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actinobacillus Infections
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therapy Actinobacillus actinomycetemcomitans / isolation & purification Adult Aggressive Periodontitis / microbiology, therapy* Amoxicillin / therapeutic use* Anti-Bacterial Agents / therapeutic use* Anti-Infective Agents / therapeutic use* Bacteroidaceae Infections / therapy Bacteroides / classification Bacteroides Infections / therapy Chronic Periodontitis / microbiology, therapy* Colony Count, Microbial Combined Modality Therapy Dental Scaling* Drug Combinations Follow-Up Studies Humans Metronidazole / therapeutic use* Middle Aged Periodontal Attachment Loss / microbiology, therapy Periodontal Index Periodontal Pocket / microbiology, therapy Placebos Porphyromonas gingivalis / isolation & purification Prevotella intermedia / isolation & purification Root Planing* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Drug Combinations; 0/Placebos; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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