| Short-term effects of replacing milk with cola beverages on insulin-like growth factor-I and insulin-glucose metabolism: a 10 d interventional study in young men. | |
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MedLine Citation:
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PMID: 19772696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the Western world, a trend towards increased consumption of carbonated soft drinks combined with a decreasing intake of milk is observed. This may affect circulating insulin-like growth factor I (IGF-I) and fasting insulin, as seen in pre-pubertal children. The present study was designed to reflect the trend of replacing milk with carbonated beverages in young men and to study the effects of this replacement on IGF-I, IGF-binding protein 3 (IGFBP-3), IGF-I:IGFBP-3 and glucose-insulin metabolism. A randomised, controlled crossover intervention study, in which eleven men aged 22-29 years were given a low-Ca diet in two 10 d periods with 10 d washout in between. In one period, they drank 2.5 litres of Coca Cola(R) per day and the other period 2.5 litres of semi-skimmed milk. Serum IGF-I, IGFBP-3 (RIA), insulin (fluoro immunoassay) and glucose (Cobas) were determined at baseline and end point of each intervention period. Insulin resistance and beta-cell function were calculated with the homeostasis model assessment. A decrease in serum IGF-I was observed in the cola period compared with the milk period (P < 0.05). No effects of treatment were observed on IGFBP-3, IGF-I:IGFBP-3, insulin, glucose, insulin resistance or beta-cell function. The present study demonstrates that high intake of cola over a 10 d period decreases total IGF-I compared with a high intake of milk, with no effect on glucose-insulin metabolism in adult men. It is unknown whether this is a transient phenomenon or whether it has long-term consequences. |
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Authors:
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Camilla Hoppe; Mette Kristensen; Marlene Boiesen; Jane Kudsk; Kim Fleischer Michaelsen; Christian Mølgaard |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-09-22 |
Journal Detail:
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Title: The British journal of nutrition Volume: 102 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1047-51 Citation Subset: IM |
Affiliation:
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Department of Human Nutrition, University of Copenhagen, Fredericksberg, Denmark. cahop@food.dtu.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Anthropometry / methods Blood Glucose / metabolism* Cola* Cross-Over Studies Diet Humans Insulin / blood* Insulin-Like Growth Factor Binding Proteins / blood Insulin-Like Growth Factor I / metabolism* Male Milk* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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