| Short-term effects of biocorrodible iron stents in porcine coronary arteries. | |
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MedLine Citation:
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PMID: 18086136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Biocorrodible iron stents carry the potential to overcome limitations, such as chronic inflammation and premature recoil, posed by biodegradable polymer and magnesium alloy stents. This study aimed to test the safety and efficacy of biocorrodible iron stents in porcine coronary arteries. METHODS: Iron stents and cobalt chromium stents were randomly deployed in the coronary arteries of juvenile domestic pigs. Animals were sacrificed at 28 days, and the vessels were fixed and processed for histochemistry. RESULTS: At 28 days, iron stents started to show signs of degradation without evidence of stent particle embolization or thrombosis without traces of excess inflammation, or fibrin deposition. At 28 days, the surface of the iron stent struts was black to brown and the vascular wall adjacent to the iron stent had a brownish tinge. There were no statistically significant differences in any of the measured parameters between segments implanted with iron and cobalt chromium stents. There were also no adverse effects in the persistent areas. CONCLUSION: The current study demonstrates that stents made of biocorrodible iron are safe. In some of the measured parameters, such as intimal thickness, intimal area, and percentage occlusion, there was a trend in favor of the iron stents. |
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Authors:
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Ron Waksman; Rajbabu Pakala; Richard Baffour; Rufus Seabron; David Hellinga; Fermin O Tio |
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Publication Detail:
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Type: Journal Article Date: 2007-12-11 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 21 ISSN: 0896-4327 ISO Abbreviation: J Interv Cardiol Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-07 Completed Date: 2008-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA. ron.waksman@medstar.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / adverse effects* Chromium Cobalt Coronary Artery Disease / surgery* Coronary Restenosis / etiology Coronary Thrombosis / etiology Coronary Vessels / pathology* Fibrin Inflammation / etiology Iron Compounds* Stents* / adverse effects Swine |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Iron Compounds; 7440-47-3/Chromium; 7440-48-4/Cobalt; 9001-31-4/Fibrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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