Document Detail


Short-term effects of biocorrodible iron stents in porcine coronary arteries.
MedLine Citation:
PMID:  18086136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Biocorrodible iron stents carry the potential to overcome limitations, such as chronic inflammation and premature recoil, posed by biodegradable polymer and magnesium alloy stents. This study aimed to test the safety and efficacy of biocorrodible iron stents in porcine coronary arteries. METHODS: Iron stents and cobalt chromium stents were randomly deployed in the coronary arteries of juvenile domestic pigs. Animals were sacrificed at 28 days, and the vessels were fixed and processed for histochemistry. RESULTS: At 28 days, iron stents started to show signs of degradation without evidence of stent particle embolization or thrombosis without traces of excess inflammation, or fibrin deposition. At 28 days, the surface of the iron stent struts was black to brown and the vascular wall adjacent to the iron stent had a brownish tinge. There were no statistically significant differences in any of the measured parameters between segments implanted with iron and cobalt chromium stents. There were also no adverse effects in the persistent areas. CONCLUSION: The current study demonstrates that stents made of biocorrodible iron are safe. In some of the measured parameters, such as intimal thickness, intimal area, and percentage occlusion, there was a trend in favor of the iron stents.
Authors:
Ron Waksman; Rajbabu Pakala; Richard Baffour; Rufus Seabron; David Hellinga; Fermin O Tio
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Publication Detail:
Type:  Journal Article     Date:  2007-12-11
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  21     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-07     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA. ron.waksman@medstar.net
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / adverse effects*
Chromium
Cobalt
Coronary Artery Disease / surgery*
Coronary Restenosis / etiology
Coronary Thrombosis / etiology
Coronary Vessels / pathology*
Fibrin
Inflammation / etiology
Iron Compounds*
Stents* / adverse effects
Swine
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Iron Compounds; 7440-47-3/Chromium; 7440-48-4/Cobalt; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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