Document Detail


Short-term effects of atenolol in patients with dilated cardiomyopathy.
MedLine Citation:
PMID:  9623012     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dilated cardiomyopathy is a common cause of heart failure with systolic dysfunction. Medications used to treat this condition are usually for symptomatic relief. We studied the effect of atenolol in heart failure caused by dilated cardiomyopathy in a double blinded randomized fashion. There were 17 males and 5 females. All patients underwent right and left heart catheterization, coronary angiography, endomyocardial biopsy, exercise testing and doppler echocardiography. By 3 months, atenolol significantly reduced resting and exercise heart rate and pulmonary capillary wedge pressure. There was no difference in exercise capacity. We conclude from this study that atenolol improve hemodynamic condition in patients with dilated cardiomyopathy without improving exercise capacity during this short observation period.
Authors:
R Krittayaphong; N Mahanonda; C Kangkagate; R Phankingthongkum; S Chaithiraphan
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  81     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-07-30     Completed Date:  1998-07-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
Affiliation:
Her Majesty's Cardiac Center, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Adult
Atenolol / therapeutic use*
Cardiomyopathy, Dilated / drug therapy*,  physiopathology
Chi-Square Distribution
Double-Blind Method
Echocardiography
Exercise Test
Female
Hemodynamics
Humans
Male
Middle Aged
Pulmonary Wedge Pressure / drug effects*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 29122-68-7/Atenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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