| Short-term effects of angiotensin II receptor blockade in patients with primary glomerulonephritis: pilot study. | |
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MedLine Citation:
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PMID: 11953926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: There is evidence that angiotensin II, the main effector of renin-angiotensin system, plays a crucial role in the pathogenesis of chronic renal injury. Angiotensin II type 1 (AT-1) receptor blockers reduce renin-angiotensin system activity by blocking the receptor, the activation of which is responsible for the majority of deleterious angiotensin II effects. The aim of the present study was to investigate renal and metabolic effects of specific AT-1 receptor blocker-losartan in patients with primary glomerulonephritis. DESIGN: Pilot clinical study. SETTING: Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Poland. PARTICIPANTS: Fifteen patients aged 43.3 +/- 11.3 years with primary glomerulonephritis confirmed by renal biopsy were studied. INTERVENTION: Creatinine clearance, urinary excretion of protein and uric acid, urinary activity of N-acetyl-beta-D-glucosaminidase, and serum concentrations of lipids, protein, and uric acid were evaluated before and after 3 months of losartan (Cozaar; Merck Sharp & Dohme, Harlow, Essex, United Kingdom) treatment at a dose of 25 mg daily. RESULTS: We found a significant reduction of urinary excretion of protein (P <.008; average, 32%). Results also revealed a decrease of serum uric acid level (P <.01), probably as a consequence of elevated uric acid urinary excretion (P <.09). No significant changes in creatinine clearance, N-acetyl-beta-D-glucosaminidase activity, protein, or lipid levels were observed. CONCLUSION: We concluded that losartan treatment at a small dose of 25 mg daily produces antiproteinuric effect without adverse effects, notably with no decrease of glomerular filtration, and simultaneously induces beneficial changes in purine metabolism. |
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Authors:
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Leszek Tylicki; Marcin Renke; Przemyslaw Rutkowski; Boleslaw Rutkowski |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation Volume: 12 ISSN: 1051-2276 ISO Abbreviation: J Ren Nutr Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-15 Completed Date: 2002-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9112938 Medline TA: J Ren Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 122-5 Citation Subset: IM |
Copyright Information:
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Copyright 2002 by the National Kidney Foundation, Inc. |
Affiliation:
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Department of Nephrology, Transplantology and Internal Medicine, Medical University, Gdańsk, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin II / antagonists & inhibitors* Antihypertensive Agents / therapeutic use*, urine Female Glomerulonephritis / drug therapy*, urine Humans Losartan / therapeutic use*, urine Male Middle Aged Pilot Projects Receptors, Angiotensin / antagonists & inhibitors* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 114798-26-4/Losartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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