Document Detail


Short-term effect of portal vein arterialization on hepatic protein synthesis and endotoxaemia after extended hepatectomy in dogs.
MedLine Citation:
PMID:  9407325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effect of partial portal arterialization on the remaining liver after usually lethal extended hepatectomy, 30 mongrel dogs underwent 84% partial hepatectomy and were divided into three groups as follows: group 1, 84% partial hepatectomy (n = 10); group 2, 84% partial hepatectomy and splenectomy (n = 10); group 3, 84% partial hepatectomy and splenectomy and splenic artery-vein (A-V) shunt (n = 10). Another five dogs were pre-operatively killed normal controls. Portal vein flow (PVF) decreased to about 60% in groups 1 and 2, but PVF in group 3 was maintained at the pre-operative level. Oxygen saturation of portal vein blood increased markedly, to between 83% (group 1) and 88% (group 3). Portal vein pressure (PVP) increased in groups 1 and 2 by 1.6 to 1.7 times the pre-operative value, but no significant difference in PVP, serum aspartate aminotransferase (AST) and arterial ketone body ratio was found between the three groups. Plasma endotoxin levels after 84% partial hepatectomy were significantly lower in group 3 than in groups 1 and 2. Both of hepatocellular and secretory protein synthesis were enhanced in group 3 compared with the other two groups. These results suggest that partial portal arterialization using a splenic A-V shunt might bring about a beneficial effect on remaining liver function after extended hepatectomy.
Authors:
A Ogata; M Miyazaki; S Ohtawa; M Ohtsuka; N Nakajima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  12     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-27     Completed Date:  1998-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  633-8     Citation Subset:  IM    
Affiliation:
First Department of Surgery, School of Medicine, Chiba University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriovenous Shunt, Surgical*
Aspartate Aminotransferases / blood,  metabolism
Blood Pressure / physiology
Dogs
Endotoxins / blood*
Hepatectomy*
Leucine / metabolism
Liver / metabolism*
Mitochondria, Liver / metabolism
Oxygen / blood
Portal Vein / physiopathology,  surgery*
Postoperative Period
Protein Biosynthesis*
Regional Blood Flow / physiology
Spleen / blood supply
Time Factors
Chemical
Reg. No./Substance:
0/Endotoxins; 61-90-5/Leucine; 7782-44-7/Oxygen; EC 2.6.1.1/Aspartate Aminotransferases

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