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Short-term effect of partially hydrolyzed formula on the prevention of development of atopic dermatitis in infants at high risk.
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MedLine Citation:
PMID:  12923332     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This short-term, prospective study was aimed to assess the effects of partially hydrolyzed formula (PHF) on the prevention of the development of atopic dermatitis in infants at high risk. The infants of parents with allergy symptoms and serum total IgE over 200 kU/L were divided into 3 groups by their feeding patterns: PHF group (n=15), standard formula (SF) group (n=32), and breast milk (BM) group (n=22). No allergenic food was given during the study period of 6 months, and breastfeeding mothers avoided egg ingestion. Their atopic symptoms were monitored every 2 months. The cumulative incidence and prevalence of atopic dermatitis at the age of 6 months were significantly less in the PHF group than in the SF group (47% vs. 78%, p<0.05; 20% vs. 59%, p<0.05). Those rates of the PHF group were also less than those of the BM group, but they were not statistically significant. There was no difference in the onset age and disease severity. These results suggest that early feeding of PHF to infants at high risk has a short-term preventive effect on the development of atopic dermatitis during the first 6 months of life. Long-term preventive effects should be evaluated.
Authors:
Young-Shin Han; Hwa-Young Park; Kang-Mo Ahn; Ju-Seok Lee; Hay-Mie Choi; Sang-Il Lee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  18     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-04-30     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding
Dermatitis, Atopic / etiology*,  prevention & control*
Electrophoresis, Polyacrylamide Gel
Female
Food Hypersensitivity
Humans
Hydrolysis
Hypersensitivity
Immunoglobulin E / blood
Infant
Infant Food*
Infant, Newborn
Male
Milk, Human
Prospective Studies
Protein Hydrolysates / therapeutic use*
Risk
Time Factors
Chemical
Reg. No./Substance:
0/Protein Hydrolysates; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 8 Year: 2003
Volume: 18 Issue: 4
First Page: 547 Last Page: 551
ID: 3055093
PubMed Id: 12923332
Publisher Item Identifier: 200308547

Short-term effect of partially hydrolyzed formula on the prevention of development of atopic dermatitis in infants at high risk.
Young-Shin Han
Hwa-Young Park
Kang-Mo Ahn
Ju-Seok Lee
Hay-Mie Choi
Sang-Il Lee
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.


Article Categories:
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