| Short-term effect of dipyridamole on blood flow velocities in the extraocular vessels. | |
| | |
MedLine Citation:
|
PMID: 8970869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dipyridamole is known to inhibit platelet aggregation and to induce vasodilatation. It has been shown that dipyridamole increases blood flow in various tissues in humans as well as in the eyes of animals. We studied the influence of dipyridamole in a prospective open trial in 23 patients with impaired ocular circulation due to different causes, based on experienced clinical judgement, such as anterior ischemic optic neuropathy, vasospastic syndrome, glaucoma, or central retinal vein occlusion. Blood flow velocities in the ophthalmic artery, central retinal artery and vein, one lateral and one medical posterior ciliary artery were measured using a Siemens Quantum 2000 color Doppler device. Blood flow velocities were measured before and under treatment. Dipyridamole increased blood flow velocities significantly in all vessels measured. Therefore, it seems promising to evaluate the effect of dipyridamole over a longer period in patients with impaired ocular blood flow. |
| | |
Authors:
|
H J Kaiser; D Stümpfig; J Flammer |
Related Documents
:
|
4028789 - Blood flow in aphakic rabbit eyes after sub-chronic glaucoma drug treatment. 11053299 - Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats. 18840429 - Retinal arteriolar and capillary vascular reactivity in response to isoxic hypercapnia. 9176899 - Ocular blood flow in experimental glaucoma: a study in cynomolgus monkeys. 3745049 - Regulation of local oxygen tension and blood flow in the inner retina during hyperoxia. 7102799 - Effect of tropicamide on ocular blood flow in the rabbit. 16943789 - Blood collection from the tail of a rat. 22661609 - Local flicker stimulation evokes local retinal blood velocity changes. 17390549 - The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men wi... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: International ophthalmology Volume: 19 ISSN: 0165-5701 ISO Abbreviation: Int Ophthalmol Publication Date: 1995-1996 |
Date Detail:
|
Created Date: 1997-03-13 Completed Date: 1997-03-13 Revised Date: 2006-07-19 |
Medline Journal Info:
|
Nlm Unique ID: 7904294 Medline TA: Int Ophthalmol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 355-8 Citation Subset: IM |
Affiliation:
|
University Eye Clinic Basel, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Blood Flow Velocity / drug effects Ciliary Body / blood supply, drug effects, physiopathology, ultrasonography Dipyridamole / pharmacology* Eye / blood supply*, physiopathology Female Humans Male Middle Aged Ophthalmic Artery / drug effects, physiopathology, ultrasonography Prospective Studies Retinal Vessels / drug effects, physiopathology, ultrasonography Ultrasonography, Doppler, Color Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diode laser photocoagulation of choroidal neovascular membranes.
Next Document: The effectiveness of dapiprazole in preventing exercise-induced IOP increase in patients with pigmen...