| Short-term effect of cocoa product consumption on lipid profile: a meta-analysis of randomized controlled trials. | |
| | |
MedLine Citation:
|
PMID: 20504978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The effect of cocoa products on lipid changes is controversial. OBJECTIVES: We aimed to identify and quantify the effect of cocoa on total cholesterol, LDL cholesterol, and HDL cholesterol. DESIGN: A comprehensive literature search was conducted for relevant trials of cocoa on lipid profile. Weighted mean differences were calculated for net changes in lipid concentrations by using fixed-effects or random-effects models. Previously defined subgroup analyses were performed to identify the source of heterogeneity. RESULTS: Eight trials (involving 215 participants) were included and evaluated. Because there was only one relatively longer-term study, we focused on the short-term data to evaluate the effects of cocoa on plasma lipid. Cocoa consumption significantly lowered LDL cholesterol by 5.87 mg/dL (95% CI: -11.13, -0.61; P < 0.05) and marginally lowered total cholesterol by 5.82 mg/dL (95% CI: -12.39, 0.76; P = 0.08). However, no significant change was seen in LDL cholesterol in high-quality studies (3 studies included; -4.98 mg/dL; 95% CI: -13.18, 3.21; P = 0.23). Subgroup analyses suggested a cholesterol-lowering effect only in those subjects who consumed a low dose of cocoa and with cardiovascular disease risks. There was no evidence of a dose-effect relation, of any effect in healthy subjects, or of any change in HDL cholesterol. CONCLUSIONS: Short-term cocoa consumption significantly reduced blood cholesterol, but the changes were dependent on the dose of cocoa consumption and the healthy status of participants. There was no dose response and no effect in healthy participants. Future high-quality studies are needed to determine the efficiency of moderate cocoa consumption on lipid profile in long-term intervention and in subjects with other cardiometabolic risk factors. |
| | |
Authors:
|
Lei Jia; Xuan Liu; Yong Yi Bai; Shao Hua Li; Kai Sun; Chen He; Rutai Hui |
Related Documents
:
|
9199268 - Alterations in plasma lipids, lipoproteins and high density lipoprotein subfractions in... 8142338 - Determinants of plasma cholesterol responsiveness to diet. 2081608 - Randomised two way crossover comparison of the effects of six weeks propranolol and ace... 20574598 - Ceramides and barrier function in healthy skin. 12839278 - Cholesterol metabolism in 8 to 12-year-old children born preterm or at term. 4037508 - Effects of deficient and adequate dietary magnesium concentrations on body magnesium co... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-21 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 218-25 Citation Subset: AIM; IM |
Affiliation:
|
Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anticholesteremic Agents
/
pharmacology* Cacao* Cardiovascular Diseases / epidemiology* Cholesterol / blood Cholesterol, HDL / blood*, drug effects Cholesterol, LDL / blood*, drug effects Female Flavonoids / pharmacology Humans Male Phenols / pharmacology Randomized Controlled Trials as Topic Reference Values Research Design Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Flavonoids; 0/Phenols; 0/polyphenols; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metab...
Next Document: Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-expo...