Document Detail

Short-term dynamics in fibrillatory wave characteristics at the onset of paroxysmal atrial fibrillation in humans.
MedLine Citation:
PMID:  17349458     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The purpose of this study was to investigate the magnitude and time course of fibrillatory wave dynamics during spontaneous onset of paroxysmal atrial fibrillation (AF). METHODS: We studied fibrillatory waves in Holter recordings of paroxysmal AF with regard to the fibrillation-free interval (FFI) preceding each episode. RESULTS: For 38 episodes of paroxysmal AF in 20 patients, dominant frequency (DF) ranged from 4.4 to 6.8 Hz (5.5 +/- 0.5 Hz). Long-FFI episodes showed a gradual increase in DF over the first 4 minutes (P < .0001). Short-FFI episodes showed an increase only from the first to the second minute (P < .003). For all 7 patients exhibiting both long-FFI and short-FFI episodes, short-FFI episodes had a higher initial DF (P < .002). CONCLUSION: The dynamics during onset and their relation to the FFI are consistent with the influence of short-term electrophysiological changes and their reversal. These findings have implications for the timing of antifibrillatory interventions.
Simona Petrutiu; Alan V Sahakian; Steven Swiryn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  40     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-04-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, USA.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / diagnosis*
Diagnosis, Computer-Assisted / methods*
Electrocardiography, Ambulatory / methods*
Middle Aged
Reproducibility of Results
Risk Assessment / methods*
Risk Factors
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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