Document Detail

Short-term digital surface microscopic monitoring of atypical or changing melanocytic lesions.
MedLine Citation:
PMID:  11735708     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the outcome of short-term digital surface microscopic monitoring of suspicious or changing atypical melanocytic lesions. DESIGN: Digital surface microscopic (oil epiluminescence microscopy, and dermoscopy) images of clinically melanocytic lesions were taken with a color calibrated 3 CCD video instrument. In general, lesions were moderately atypical, flat or only slightly raised, without a history of change or surface microscopic evidence of melanoma, or were mildly atypical lesions with a history of change. Lesions were monitored during a 2.5- to 4.5-month period (median, 3.0 months). With the exception of overall change in pigmentation consistent with that seen in surrounding skin (solar exposure changes), any morphologic change after monitoring was considered an indication to excise. SETTING: Sydney Melanoma Unit, Sydney, Australia (a referral center). PATIENTS: A consecutive sample of 318 lesions from 245 patients (aged 4-81 years). MAIN OUTCOME MEASURE: Specificity for the diagnosis of melanoma. RESULTS: Of the 318 lesions, 81% remained unchanged. Of the 61 lesions that showed morphologic changes, 7 (11% of changed and 2% of total lesions) were found to be early melanoma (5 in situ and 2 invasive with a Breslow thickness of 0.25 mm and 0.28 mm, respectively). None of these melanomas developed any classic surface microscopic features of melanoma and therefore could be identified only by morphologic change. The specificity for the diagnosis of melanoma by means of short-term digital monitoring was 83%. CONCLUSION: On the assumption that all melanoma will change during the monitored period, surface microscopy digital monitoring is a useful adjunct for the management of melanocytic lesions.
S W Menzies; A Gutenev; M Avramidis; A Batrac; W H McCarthy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of dermatology     Volume:  137     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-08     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1583-9     Citation Subset:  AIM; IM    
Sydney Melanoma Unit, Melanoma and Skin Cancer Unit, Department of Surgery, University of Sydney, Australia.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Diagnosis, Differential
Diagnostic Imaging / standards*
Melanoma / pathology*
Middle Aged
Nevus, Pigmented / pathology*
Predictive Value of Tests
Sensitivity and Specificity
Skin Neoplasms / pathology*
Skin Pigmentation
Time Factors
Comment In:
Arch Dermatol. 2001 Dec;137(12):1641-4   [PMID:  11735717 ]
Arch Dermatol. 2002 Oct;138(10):1378-9   [PMID:  12374550 ]

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