| Short-term dietary lipid manipulation does not affect survival in two models of murine sepsis. | |
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MedLine Citation:
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PMID: 1640632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary lipid manipulation has been shown to have various effects on the immune system, depending on the amount of fat, degree of saturation, and type of fat used. In this study we investigated the role of different sources of fat at different levels on the survival of mice in two models of peritonitis, one with Pseudomonas aeruginosa and the other with Salmonella typhimurium. CF1 mice were pair-fed diets with 5% or 40% of total calories as fat. The source of fat used was coconut oil, oleic acid, safflower oil, or fish oil. Three other diets were tested as well, one with no fat, one with only 0.5% of total calories linoleic acid as the only source of fat, and a control diet that had 12% of total calories as corn oil. At the end of 2 weeks of feeding the experimental diets, mice were challenged with Ps aeruginosa intraperitoneally and mortality was recorded over 1 week. After 3 weeks of feeding the experimental diets, mice were challenged with S typhimurium and mortality was recorded over 2 weeks. No significant differences were seen on survival among groups fed different levels of fat, as well as different sources of fat. We conclude that, overall, 2- and 3-week manipulation of dietary fat does not affect outcome from infection in these models. |
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Authors:
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P Clouva-Molyvdas; M D Peck; J W Alexander |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 16 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 1992 Jul-Aug |
Date Detail:
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Created Date: 1992-09-03 Completed Date: 1992-09-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 343-7 Citation Subset: IM |
Affiliation:
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Shriners Burns Institute, Cincinnati, Ohio. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Fats / administration & dosage* Dietary Fats, Unsaturated / administration & dosage Disease Models, Animal* Female Linoleic Acid Linoleic Acids / administration & dosage Mice Oleic Acid Oleic Acids / administration & dosage Peritonitis / mortality* Plant Oils / administration & dosage Pseudomonas Infections / mortality Safflower Oil / administration & dosage Salmonella Infections, Animal / mortality Salmonella typhimurium Survival Rate Weight Gain |
| Grant Support | |
ID/Acronym/Agency:
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AI12936/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Linoleic Acids; 0/Oleic Acids; 0/Plant Oils; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 8001-23-8/Safflower Oil; 8001-31-8/coconut oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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