Document Detail

Short-term dietary lipid manipulation does not affect survival in two models of murine sepsis.
MedLine Citation:
PMID:  1640632     Owner:  NLM     Status:  MEDLINE    
Dietary lipid manipulation has been shown to have various effects on the immune system, depending on the amount of fat, degree of saturation, and type of fat used. In this study we investigated the role of different sources of fat at different levels on the survival of mice in two models of peritonitis, one with Pseudomonas aeruginosa and the other with Salmonella typhimurium. CF1 mice were pair-fed diets with 5% or 40% of total calories as fat. The source of fat used was coconut oil, oleic acid, safflower oil, or fish oil. Three other diets were tested as well, one with no fat, one with only 0.5% of total calories linoleic acid as the only source of fat, and a control diet that had 12% of total calories as corn oil. At the end of 2 weeks of feeding the experimental diets, mice were challenged with Ps aeruginosa intraperitoneally and mortality was recorded over 1 week. After 3 weeks of feeding the experimental diets, mice were challenged with S typhimurium and mortality was recorded over 2 weeks. No significant differences were seen on survival among groups fed different levels of fat, as well as different sources of fat. We conclude that, overall, 2- and 3-week manipulation of dietary fat does not affect outcome from infection in these models.
P Clouva-Molyvdas; M D Peck; J W Alexander
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  16     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1992 Jul-Aug
Date Detail:
Created Date:  1992-09-03     Completed Date:  1992-09-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
Shriners Burns Institute, Cincinnati, Ohio.
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MeSH Terms
Dietary Fats / administration & dosage*
Dietary Fats, Unsaturated / administration & dosage
Disease Models, Animal*
Linoleic Acid
Linoleic Acids / administration & dosage
Oleic Acid
Oleic Acids / administration & dosage
Peritonitis / mortality*
Plant Oils / administration & dosage
Pseudomonas Infections / mortality
Safflower Oil / administration & dosage
Salmonella Infections, Animal / mortality
Salmonella typhimurium
Survival Rate
Weight Gain
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Linoleic Acids; 0/Oleic Acids; 0/Plant Oils; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 8001-23-8/Safflower Oil; 8001-31-8/coconut oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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