Document Detail


Short-term couplings of the cardiovascular system in pregnant women suffering from pre-eclampsia.
MedLine Citation:
PMID:  20368244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pre-eclampsia (PE), a serious pregnancy-specific disorder, causes significant neonatal and maternal morbidity and mortality. Recent studies showed that cardiovascular variability parameters as well as the baroreflex sensitivity remarkably improve its early diagnosis. For a better understanding of the dynamical changes caused by PE, in this study the coupling between respiration, systolic and diastolic blood pressure, and heart rate is investigated. Thirteen datasets of healthy pregnant women and 10 of subjects suffering from PE are included. Nonlinear additive autoregressive models with external input are used for a model-based coupling analysis following the idea of Granger causality. To overcome the problem of misdetections of standard methods in systems with a dominant driver, a heuristic ensemble approach is used here. A coupling is assumed to be real when existent in more than 80 per cent of the ensemble members, and otherwise denoted as artefacts. As the main result, we found that the coupling structure between heart rate, systolic blood pressure, diastolic blood pressure and respiration for healthy subjects and PE patients is the same and reliable. As a pathological mechanism, however, a significant increased respiratory influence on the diastolic blood pressure could be found for PE patients (p=0.003). Moreover, the nonlinear form of the respiratory influence on the heart rate is significantly different between the two groups (p=0.002). Interestingly, the influence of systolic blood pressure on the heart rate is not selected, which indicates that the baroreflex sensitivity estimation strongly demands the consideration of causal relationships between heart rate, blood pressure and respiration. Finally, our results point to a potential role of respiration for understanding the pathogenesis of PE.
Authors:
Maik Riedl; Alexander Suhrbier; Holger Stepan; Jürgen Kurths; Niels Wessel
Related Documents :
21147054 - Associations between sociocultural pressures to be thin, body distress, and eating diso...
10234094 - Overview of epidemiological studies on ambulatory blood pressure in spain.
8081324 - Difference in the cardiovascular response to prolonged sitting in men and women.
2258884 - Differences in ambulatory blood pressure between men and women with mild hypertension.
9832744 - A randomised controlled trial of two pressure-reducing surfaces.
16256434 - Immersion in warm water induces improvement in cardiac function in patients with chroni...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Philosophical transactions. Series A, Mathematical, physical, and engineering sciences     Volume:  368     ISSN:  1364-503X     ISO Abbreviation:  Philos Trans A Math Phys Eng Sci     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-08-16     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  101133385     Medline TA:  Philos Trans A Math Phys Eng Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2237-50     Citation Subset:  IM    
Affiliation:
Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Blood Pressure
Cardiovascular System / physiopathology*
Case-Control Studies
Female
Heart Rate
Humans
Models, Biological
Pre-Eclampsia / physiopathology*
Pregnancy
Respiration
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phase-resolved analysis of the susceptibility of pinned spiral waves to far-field pacing in a two-di...
Next Document:  Memory formation: from network structure to neural dynamics.