| Short-term couplings of the cardiovascular system in pregnant women suffering from pre-eclampsia. | |
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MedLine Citation:
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PMID: 20368244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pre-eclampsia (PE), a serious pregnancy-specific disorder, causes significant neonatal and maternal morbidity and mortality. Recent studies showed that cardiovascular variability parameters as well as the baroreflex sensitivity remarkably improve its early diagnosis. For a better understanding of the dynamical changes caused by PE, in this study the coupling between respiration, systolic and diastolic blood pressure, and heart rate is investigated. Thirteen datasets of healthy pregnant women and 10 of subjects suffering from PE are included. Nonlinear additive autoregressive models with external input are used for a model-based coupling analysis following the idea of Granger causality. To overcome the problem of misdetections of standard methods in systems with a dominant driver, a heuristic ensemble approach is used here. A coupling is assumed to be real when existent in more than 80 per cent of the ensemble members, and otherwise denoted as artefacts. As the main result, we found that the coupling structure between heart rate, systolic blood pressure, diastolic blood pressure and respiration for healthy subjects and PE patients is the same and reliable. As a pathological mechanism, however, a significant increased respiratory influence on the diastolic blood pressure could be found for PE patients (p=0.003). Moreover, the nonlinear form of the respiratory influence on the heart rate is significantly different between the two groups (p=0.002). Interestingly, the influence of systolic blood pressure on the heart rate is not selected, which indicates that the baroreflex sensitivity estimation strongly demands the consideration of causal relationships between heart rate, blood pressure and respiration. Finally, our results point to a potential role of respiration for understanding the pathogenesis of PE. |
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Authors:
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Maik Riedl; Alexander Suhrbier; Holger Stepan; Jürgen Kurths; Niels Wessel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Volume: 368 ISSN: 1364-503X ISO Abbreviation: Philos Trans A Math Phys Eng Sci Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-08-16 Revised Date: 2013-04-24 |
Medline Journal Info:
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Nlm Unique ID: 101133385 Medline TA: Philos Trans A Math Phys Eng Sci Country: England |
Other Details:
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Languages: eng Pagination: 2237-50 Citation Subset: IM |
Affiliation:
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Department of Physics, Humboldt-Universität zu Berlin, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Blood Pressure Cardiovascular System / physiopathology* Case-Control Studies Female Heart Rate Humans Models, Biological Pre-Eclampsia / physiopathology* Pregnancy Respiration Time Factors |
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