| Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men. | |
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MedLine Citation:
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PMID: 21106937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recently showed that a short-term high-fat diet blunted exercise performance in rats, accompanied by increased uncoupling protein levels and greater respiratory uncoupling. In this study, we investigated the effects of a similar diet on physical and cognitive performance in humans. Twenty sedentary men were assessed when consuming a standardized, nutritionally balanced diet (control) and after 7 d of consuming a diet comprising 74% kcal from fat. Efficiency was measured during a standardized exercise task, and cognition was assessed using a computerized assessment battery. Skeletal muscle mitochondrial function was measured using (31)P magnetic resonance spectroscopy. The diet increased mean ± se plasma free fatty acids by 44% (0.32±0.03 vs. 0.46±0.05 mM; P<0.05) and decreased whole-body efficiency by 3% (21±1 vs. 18±1%; P<0.05), although muscle uncoupling protein (UCP3) content and maximal mitochondrial function were unchanged. High-fat diet consumption also increased subjects' simple reaction times (P<0.01) and decreased power of attention (P<0.01). Thus, we have shown that a high-fat diet blunts whole-body efficiency and cognition in sedentary men. We suggest that this effect may be due to increased respiratory uncoupling. |
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Authors:
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Lindsay M Edwards; Andrew J Murray; Cameron J Holloway; Emma E Carter; Graham J Kemp; Ion Codreanu; Helen Brooker; Damian J Tyler; Peter A Robbins; Kieran Clarke |
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Publication Detail:
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Type: Journal Article Date: 2010-11-24 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 25 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2011-04-28 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 1088-96 Citation Subset: IM |
Affiliation:
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Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK. l.m.edwards@utas.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cognition / physiology* Dietary Fats / adverse effects*, pharmacokinetics Energy Metabolism / physiology* Exercise / physiology* Exercise Test Humans Ion Channels / metabolism Magnetic Resonance Spectroscopy Male Middle Aged Mitochondria / metabolism* Mitochondrial Proteins / metabolism Models, Biological Muscle Proteins / metabolism Muscle, Skeletal / metabolism Oxygen Consumption / physiology Phosphorus / metabolism Sedentary Lifestyle |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Ion Channels; 0/Mitochondrial Proteins; 0/Muscle Proteins; 0/mitochondrial uncoupling protein 3; 7723-14-0/Phosphorus |
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