| Short-term complexity indexes of heart period and systolic arterial pressure variabilities provide complementary information. | |
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MedLine Citation:
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PMID: 23104699 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is unclear whether complexity of the variability of systolic arterial pressure (SAP) provides complementary information compared to that of heart period (HP). Complexity of HP and SAP variabilities was assessed from short beat-to-beat recordings (i.e. 256 cardiac beats). The evaluation was made during a pharmacological protocol inducing vagal blockade with atropine and/or sympathetic blockade (beta-adrenergic blockade with propranolol or central sympathetic blockade with clonidine), during graded head-up tilt and in Parkinson's disease (PD) patients without orthostatic hypotension undergoing orthostatic challenge. Complexity was quantified according to the mean square prediction error (MSPE) derived from univariate autoregressive (AR) and multivariate AR (MAR) models. We found that: i) MSPE(MAR) did not provide additional information compared to MSPE(AR); ii) SAP variability was less complex than HP one; iii) since HP complexity was reduced by either vagal blockade or vagal withdrawal induced by head-up tilt, and was unaffected by beta-adrenergic blockade, it was under vagal control; iv) since SAP complexity was increased by central sympathetic blockade, and was unmodified by either vagal blockade or vagal withdrawal induced by head-up tilt, it was under sympathetic control; v) SAP complexity was increased in PD patients; vi) during orthostatic challenge complexity of both HP and SAP variabilities in PD patients remained high, thus indicating both vagal and sympathetic impairments. Complexity indexes derived from short HP and SAP beat-to-beat series provide complementary information and are helpful to detect early autonomic dysfunction in PD group well before circulatory symptoms become noticeable. |
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Authors:
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Alberto Porta; Paolo Castiglioni; Marco Di Rienzo; Vlasta Bari; Tito Bassani; Andrea Marchi; Anielle C M Takahashi; Eleonora Tobaldini; Nicola Montano; Aparecida M Catai; Franca Barbic; Raffaello Furlan; Andrei Cividjian; Luc Quintin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-25 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Milan. |
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