Document Detail


Short-term complexity indexes of heart period and systolic arterial pressure variabilities provide complementary information.
MedLine Citation:
PMID:  23104699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is unclear whether the complexity of the variability of the systolic arterial pressure (SAP) provides complementary information to that of the heart period (HP). The complexity of HP and SAP variabilities was assessed from short beat-to-beat recordings (i.e., 256 cardiac beats). The evaluation was made during a pharmacological protocol that induced vagal blockade with atropine or a sympathetic blockade (beta-adrenergic blockade with propranolol or central sympathetic blockade with clonidine) alone or in combination, during a graded head-up tilt, and in patients with Parkinson's disease (PD) without orthostatic hypotension undergoing orthostatic challenge. Complexity was quantified according to the mean square prediction error (MSPE) derived from univariate autoregressive (AR) and multivariate AR (MAR) models. We found that: 1) MSPE(MAR) did not provide additional information to that of MSPE(AR); 2) SAP variability was less complex than that of HP; 3) because HP complexity was reduced by either vagal blockade or vagal withdrawal induced by head-up tilt and was unaffected by beta-adrenergic blockade, HP was under vagal control; 4) because SAP complexity was increased by central sympathetic blockade and was unmodified by either vagal blockade or vagal withdrawal induced by head-up tilt, SAP was under sympathetic control; 5) SAP complexity was increased in patients with PD; and 6) during orthostatic challenge, the complexity of both HP and SAP variabilities in patients with PD remained high, thus indicating both vagal and sympathetic impairments. Complexity indexes derived from short HP and SAP beat-to-beat series provide complementary information and are helpful in detecting early autonomic dysfunction in patients with PD well before circulatory symptoms become noticeable.
Authors:
A Porta; P Castiglioni; M Di Rienzo; V Bari; T Bassani; A Marchi; A C M Takahashi; E Tobaldini; N Montano; A M Catai; F Barbic; R Furlan; A Cividjian; L Quintin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-25
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-06-14     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1810-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms*
Arterial Pressure / physiology*
Autonomic Nervous System / physiology*
Blood Pressure Determination / methods*
Electrocardiography / methods*
Female
Heart Rate / physiology*
Humans
Male
Middle Aged
Systole / physiology*
Grant Support
ID/Acronym/Agency:
GGP09247//Telethon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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