| Short-term changes in cerebral microhemodynamics after carotid stenting. | |
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MedLine Citation:
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PMID: 13679259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The cerebral hemodynamic sequelae of interventions in patients with severe internal carotid artery (ICA) stenoses are not fully understood. In this study, we sought to determine the immediate changes in cerebral perfusion characteristics, determined by MR imaging in patients who have undergone unilateral transluminal angioplasty and stent placement. METHODS: Eleven patients with symptomatic high-grade ICA stenosis underwent MR imaging within 4 hours before and within 3 hours after carotid stent placement. First-pass gadolinium-enhanced imaging of perfusion was performed by using a gradient-recalled echo-planar technique. Localized relative cerebral blood volume (rCBV) and bolus first-moment transit time (TT(FM)) were calculated for different vascular territories (middle, anterior, and posterior cerebral arteries) in each hemisphere. RESULTS: Significantly longer TT(FM) (P <.005) was observed in the symptomatic territory of the middle cerebral artery before intervention. After intervention, TT(FM) remained significantly longer in this territory (P <.05). However, the magnitude of the interhemispheric asymmetry had declined significantly (50-60% reduction; P <.05). No significant differences or changes in rCBV were identified between hemispheres, between images, or in areas of unilateral leptomeningeal enhancement after intervention. CONCLUSION: MR can demonstrate short-term partial resolution of timing asymmetry in interhemispheric perfusion after angioplasty and stent insertion for severe stenosis of the ICA. |
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Authors:
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Iain D Wilkinson; Paul D Griffiths; Nigel Hoggard; Trevor J Cleveland; Peter A Gaines; Sumaira Macdonald; Fiona McKevitt; Graham S Venables |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 24 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-18 Completed Date: 2004-01-08 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
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Languages: eng Pagination: 1501-7 Citation Subset: IM |
Affiliation:
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Academic Unit of Radiology, University of Sheffield, England. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon* Brain / blood supply* Carotid Artery, Internal* / physiopathology Carotid Stenosis / diagnosis, physiopathology, therapy* Dominance, Cerebral / physiology Female Hemodynamics / physiology Humans Magnetic Resonance Angiography* Male Middle Aged Regional Blood Flow / physiology Stents* |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 2003 Sep;24(8):1497-9
[PMID:
13679257
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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