| Short-term cephalosporin prophylaxis in transurethral surgery. | |
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MedLine Citation:
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PMID: 6293718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of three short-term prophylactic cephalosporin regimens were compared in a prospective, randomized, double-blind study. One hundred sixteen men, with sterile urine preoperatively, underwent transurethral surgery (resection of the prostate or bladder neck, 73; resection or fulguration of bladder tumors, 38; or internal urethrotomy, 5). One group received 1 gm of cefotaxime parenterally 30 to 90 minutes preoperatively, every 60 to 90 minutes during surgery, and immediately postoperatively. In the other two groups, 1 gm of cefotaxime or cefazolin was administered according to the regimen used in the first group and also every eight hours for 24 hours postoperatively. All three prophylactic regimens significantly lowered the incidence of infection three and five to seven days postoperatively, the incidence being approximately 5% as compared with an incidence of about 40% found in an earlier study in which a placebo was used. The results with the three regimens were not significantly different. Our data showed that to prevent postoperative urinary tract infection, prophylactic antibiotics need only be administered immediately perioperatively in uninfected patients who undergo transurethral surgery; longer prophylaxis is unnecessary. |
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Authors:
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P Iversen; P O Madsen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical therapeutics Volume: 5 Suppl A ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1982 |
Date Detail:
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Created Date: 1983-02-25 Completed Date: 1983-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 58-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bacteriuria / drug therapy Cefazolin / therapeutic use Cefotaxime / therapeutic use Cephalosporins / metabolism, therapeutic use* Humans Male Premedication* Prostate / surgery* Urethra / surgery* Urinary Bladder / surgery* |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 25953-19-9/Cefazolin; 63527-52-6/Cefotaxime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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